手足口病患儿淋巴细胞亚群与红细胞锌及超敏C反应蛋白水平分析

摘要

Objective To explore the level change of peripheral blood lymphocyte subgroup ,the erythrocyte zinc and hs-CRP in children with hand-foot-mouth disease (HFMD) .Methods Children with severe HFMD in this hospital were selected as experi-mental group ,and children in health that received physical examination in this hospital were selected as control group .Level of the peripheral blood lymphocyte subsets ,erythrocyte zine and hs-CRP were detected .Results In the HFMD group ,total T cell percent-age(CD3 + ) ,auxiliary/ induced T cells (CD3 + CD4 + ) percentage ,inhibit/cytotoxic T cells(CD3 + CD8 + ) percentage ,and the eryth-rocyte zine levels were all significantly lower than that of the control group(P< 0 .05) ,while the hs-CRP determination level ,B cells (CD19 + ) percentage were significantly higher than those of the control group(P< 0 .05) .Conclusion Children with severe HFMD have cellular immunity and hormone immunity function disorder and are lack of erythrocyte zinc .And their body cannot effectively resist infection virus ,which can lead to secondary bacterial infection .%目的：探讨手足口病患儿外周血淋巴细胞亚群与红细胞锌及超敏 C 反应蛋白（hs-CRP）的水平变化。方法选取该院诊疗的重型手足口病患儿为患儿组，另选取该院健康体检的健康儿童为对照组，检测外周血淋巴细胞亚群与红细胞锌及 hs-CRP 水平。结果患儿组的总 T 细胞（CD3＋）百分率、辅助／诱导 T 细胞（CD3＋ CD4＋）百分率、抑制／细胞毒 T 细胞（CD3＋CD8＋）百分率、红细胞锌测定水平明显低于对照组（P＜0．05）；hs-CRP 测定水平、B 细胞（CD19＋）百分率明显高于对照组（P＜0．05）。结论重型手足口病患儿细胞免疫和体液免疫功能紊乱、红细胞锌缺乏、机体不能有效抵御病毒感染，可导致继发细菌感染。