Palladium-catalyzed R_2(O)P-directed C(sp^2)–H activation

摘要

In recent years,transition-metal-catalyzed inert C–H bond activation has developed rapidly and is a powerful protocol for the construction of new C–C or C–X bonds and the introduction of new functional groups.Our group has also developed a series of R2(O)P-directed Pd-catalyzed C–H functionalizations involving olefination,hydroxylation,acetoxylation,arylation,and acylation through an uncommon seven-membered cyclo-palladium pretransition state.Unlike previously used directing groups,the R2(O)P group acts as a directing group and is also involved in the construction of P,-hetero-ligands.