喹硫平与舒必利对精神分裂症患者血脂代谢的影响

摘要

目的 探讨喹硫平和舒必利对精神分裂症患者血脂代谢影响,并比较男女之间的差异.方法 2006年1月至2009年1月期间入院予喹硫平或舒必利治疗的精神分裂症患者453例,分析喹硫平与舒必利治疗8周前后的空腹血胆固醇(TC)、甘油三酯(TG)浓度变化.结果 ①喹硫平治疗组胆固醇及甘油三酯前后变化不明显,差异均无统计学意义(t=1.45,P=0.13;t=1.58,P=0.10),男女间差异无统计学意义(t=1.03,P=0.28;t=1.34,P=0.16).②舒必利组治疗后胆固醇及甘油三酯明显升高(t=3.01,P=0.006;t=2.42,P=0.017),且女性胆固醇及甘油三酯升高的程度显著大于男性患者(t=2.46,P=0.019,t=2.13,P=0.034).③舒必利对胆固醇及甘油三酯的影响程度均大于喹硫平(t=2.69,P=0.008;t=2.08,P=0.021).结论 喹硫平对精神分裂症患者血脂代谢的影响不大;舒必利使血胆固醇及甘油三酯水平升高,且对女性影响大.舒必利对胆固醇及甘油三酯的影响均大于喹硫平.%Objective To explore the effects of Quetiapine and Sulpiride on serum lipid metabolism in male and female patients with schizophrenia. Method 453 schizophrenic patients registered to our hospital between January 2006 and January 2009 were included to receive Quetiapine or Sulpiride treatment. The changes in fasting serum levels of total cholesterol (TC) and triglyceride (TG) after the 8-week treatment with Quetiapine or Sulpiride from baseline were analyzed. Results (1)After Quetiapine treatment the serum levels of TC and TG (t=1.45,P=0. 13 ;t=1.58,P=0.10)did not shown any change from baseline or any difference between both genders (t=1.03,p=0.28 ;t=1.34,P=0. 16). (2)After Sulpiride treatment, significant increases in serum levels of TC and TG were shown in the patients (t=3.01,P=0.006;t=2.42,P=0.017),especially in females (t=2.46,P=0.019;t=2.13,P=0.034); (3) Sulpiride had greater effects on serum TC and TG than Quetiapine (t=2.69,P=0.008;t=2.08,P=0.021). Conclusion Quetiapine has little effects on lipid metabolism, while sulpiride induces elevated serum levels of TC and TG, especially in female patients. Sulpiride may have greater effects on serum TC and TG than Quetiapine.