神经轴突中信号转导内体运输的研究方法

摘要

The information communication between neurons and their growth and development are closely related to axonal trans-port. Signal molecules in the axonal transport activate the rele-vant receptors to form ligand-receptor complexes. The ligand-re-ceptor complexes being transported into endosomes by endocyto-sis form the cellular endocytic organelles in neuronal axons. Those cellular endocytic organelles transported from axon to cell body are called signalling endosome. When endosome transport n is impaired, it will affect neuronal survival. Understanding the study methods in this process of axonal and endosomal transport will be helpful to find out the etiopathogenesis and the therapeu-tic methods of relevant diseases. This article mainly reviews the study methods of signalling endosome transport in neuronal ax-ons.%神经元之间的信息交流及其生长发育与轴突运输密切相关。轴突运输中信号分子通过激活相关受体形成配体-n　　受体复合物，在细胞内吞作用下进入内体，形成神经元轴突中的胞内吞细胞器。胞内吞细胞器从轴突运输至胞体，这种细胞器称为信号转导内体。内体运输受损影响神经元的生存，了解轴突及内体运输这一过程的研究方法将有助于寻找相关疾病的病因和防治方法。该文就神经元轴突及内体运输的研究方法进行综述。