tuftsin及其衍生物T肽的抗癌作用研究进展

摘要

tuftsin,a physiologically active peptide,can promote phagocytosis,basically stimulates the macrophages or neutro-phils and improve their phagocytotic function.tuftsin can not di-rectly kill tumor cells.Due to its short structure and the charac-teristics of being susceptible to hydrolysis,it is difficult for tuft-sin to be made into medicine and applied clinically.However, derivatives of tuftsin-series and combination of tuftsin with other drugs can greatly enhance the cytotoxic effect on tumor cells of tuftsin.It has a broad prospect of research,especially deriva-tive-TP has a significant anti-tumor effect.Its mechanism is clear and its is expected to become a new type of anti-tumor bio-logical response regulator.%tuftsin是机体脾脏产生的一段生理活性肽，其基本功能是刺激巨噬细胞和粒细胞，提高促吞噬的能力；其对肿瘤细胞并没有直接杀伤效应，但可以通过增强效应细胞的细胞毒功能杀伤肿瘤细胞，在抗感染和抗肿瘤方面具有不可替代的作用。但由于其肽链短、易被水解的特性，至今难以成药而应用于临床。tuftsin的系列衍生物以及与其他药物联用却可提高其抗癌活性，具有广阔的研究前景；尤其是衍生物T肽具有明显的抗肿瘤作用，其作用机制基本明确，可望成为新型抗肿瘤生物反应调节剂。