龙脑促进药物经皮渗透作用的研究

摘要

目的：考察龙脑对多种药物透皮作用的影响。方法：以改良的Frang双室渗透扩散装置进行药物体外渗透试验；以家兔在体试验和人体皮肤苍白试验进行药物活体透皮试验。结果：在离体蛇蜕透皮吸收试验，龙脑增加甲硝唑、氟脲嘧啶的透皮吸收，存在剂量效应关系；在志愿者前臂内侧皮肤，龙脑提高醋酸曲安奈德的生物利用度；在整体兔，龙脑使水杨酸经皮吸收增加。结论：龙脑是一种有效的透皮促进剂。%OBJECTIVE:To observe the effects of borneol affecting the transdermal amount of drugs.METHODS:Drugs permeation tests were performed in a two-compartment diffusion cell through cobra skin in vitro,in rabbits and on the human skin blanching assay in vivo,respetively.RESULTS:In vitro,borneol increased the percutaneous transport of metronidazole and 5-fluorouracil.The potency of 3.0% borneol was different from that of 1.0%borneol.On the human skin beanching assay in vivo it indicated that borneol enhanced the bioavailability of percutaneous penetration of triamcinolone acetonide acetate.In rabbits,borneol increased AUCo～12h of salicylic acid in plasma.CONCLUSION:It indicated borneol is a effective percutaneous penetration enhancer.