健脾益肺口服液对小儿哮喘缓解期气道炎症和肺功能的影响

摘要

Objective To investigate the effects of Jianpi Yifei oral solution on serum inflammatory cytokines and lung function in children with bronchial asthma at remission stage.Methods Sixty children with bronchial asthma at remission stage admitted to Department of Pediatrics,the Second Hospital of Chaoyang,from January 2014 to February 2015,were included and divided randomly into observational group and control group,with 30 cases in each group.Jianpi Yifei oral solution and Budesonide powder for inhalation were administered for 3 months in the observational and control groups,respectively.Serum tumor necrosis factor-αand interleukin-6 and lung function were determined before and 3 months after treat-ment.Results Serum tumor necrosis factor-α,interleukin-6,forced volume vital capacity,and forced expira-tory volume in one second were significantly decreased after treatment,compared with before treatment(P <0.05).Serum tumor necrosis factor-α,interleukin-6,forced volume vital capacity,and forced expiratory volume in one second were similar before and after treatment(P >0.05).Conclusion Jianpi Yifei oral solu-tion can significantly inhibit airway inflammatory reaction and improve lung function in children with bron-chial asthma at remission stage,and the effects are similar to those of hormone drugs.%目的：观察健脾益肺口服液对哮喘缓解期患儿血清炎性细胞因子和肺功能的影响。方法2014年1月至2015年2月朝阳市第二医院儿科收治住院的缓解期哮喘患儿60例，随机分为观察组和对照组各30例。观察组给予健脾益肺口服液治疗，对照组给予布地奈德粉吸入剂治疗，两组均治疗3个月。于治疗前和治疗3个月后采用酶联免疫吸附法检测患儿血清肿瘤坏死因子α和白细胞介素6水平，以及肺功能。结果两组患儿治疗后血清肿瘤坏死因子α、白细胞介素6水平以及用力肺活量（FVC）、一秒钟用力呼气量（FEVl）均明显低于治疗前，差异有统计学意义（P ＜0.05）；两组治疗后血清肿瘤坏死因子α、白细胞介素6水平以及 FVC、FEVl 比较差异无统计学意义（P ＞0.05）。结论健脾益肺口服液可明显抑制哮喘缓解期患儿气道炎症反应，改善患儿肺功能，且效果相当于激素类药物。