Prothrombin kringle-2, a mediator of microglial activation: new insight in Alzheimer’s disease pathogenesis

摘要

Microglial activation in Alzheimer’s disease(AD):In 1907,Dr.Alois Alzheimer,a Bavarian-born German psychiatrist and neuropathologist,published an article describing the clinical and neuropathological features of an unclassified psychiatric disorder.The disorder was later named AD and is currently the most common brain disorder(Takata et al.,2021).AD involves the accumulation of amyloid-β(Aβ)and hyperphosphorylated tau proteins in the brain,which are associated with senile plaques and neurofibrillary tangles,respectively(Vergara et al.,2019;Takata et al.,2021).AD is characterized by cognitive impairment and memory loss with hippocampal neurodegeneration(Kim et al.,2021).