藏药脉花党参的化学成分

摘要

AIM:To study the chemical constituents of the aerial parts of Codonopsis nervosa (Chipp.) Nannf.(Campanulaceae),a commonly used Tibetan herb.METHODS:The constituents were isolated by D-101 porous polymer resin,silica gel,ODS and Sephadex LH-20 column chromatography,and their structures were elucidated on the basis of spectroscopic analysis.RESULTS:15compounds were isolated and identified as chrysoeriol (1),tricin (2),apigenin (3),succinic acid (4),β-sitosterol-3-O-β-D-glucopyranoside (5),luteolin (6),luteolin-7-O-β-D-glucopyranoside (7),ethylsyringin (8),apigenin-7-O-β-D-glucopyranoside (9),luteolin-7-O-β-D-glucopyranosyl-(1→6)-[6('")-O-caffeoyl]-β-D-glucopyranoside (10),luteolin-7-O-β-D-gentiobioside (11),syringin (12),3-O-caffeoylquinic acid (13),5-O-caffeoylquinic acid (14),and 4-O-(β-D-glucopyranosyl)-benzoic acid (15),respectively.CONCLUSION:Compounds 1-5,8,9,12,14,15 were reported from C.nervosa for the first time.%目的:研究藏药脉花党参Codonopsis nervosa (Chipp.) Nannf.地上部分的化学成分.方法:采用D101大孔树脂柱、硅胶柱、ODS柱、凝胶柱等色谱手段进行化学分离和纯化,并利用各种波谱技术进行结构鉴定.结果:分离并鉴定了15个化合物,分别为柯伊利素(1),苜蓿素(2),芹菜素(3),琥珀酸(4),β-胡萝卜苷(5),木犀草素(6),木犀草素-7-O-β-D-葡萄糖苷(7),ethylsyringin (8),芹菜素-7-O-β--D-葡萄糖苷(9),木犀草素-7-O-β-D-葡萄糖基-(1→6)-[(6()-O-咖啡酸)-β-D-葡萄糖苷](10),木犀草素-7-O-β-D-龙胆二糖苷(11),丁香苷(12),绿原酸(13),新绿原酸(14),对羟基苯甲酸葡萄糖苷(15).结论:化合物1-5,8,9,12,14,15均首次从该植物中分离得到.