LIVER TRANSPLANTATION IN PATIENTS WITH FULMINANT HEPATITIS B:EXPERIENCE IN CANTON,CHINA

摘要

Objective.To investigate the effect of orthotopic liver transplantation on fulminant hepatitis B and the preventive efficiency of lamivudine on recurrence of hepatitis B in China. Patients and methods.Ten patients with fulminant hepatitis B received orthotopic liver transplantation under veno venous bypass.All patients had preoperatively serious jaundice,ascites and coagulopathy,and of whom 7 with encephalopathy,2 with acute renal failure,and 1 with gastro hemorrhage. Rusult.Seven of the 10 patients have survived for 3～18 months,but 3 died of multi organ failure or recurrence of fulminant hepatitis B.Seven survivors took lamivudine and 6 of them have survived for 3～18 months without the signs of recurrence of hepatitis B. Conclusion.Orthotopic liver transplantation is an effective therapy for fulminant hepatitis B,and lamivudine may prevent recurrence of hepatitis B after transplantation.