胃癌患者外周血淋巴细胞白介素2受体检测的临床意义

摘要

Objective To understand the clinical significance of membrane receptors of interleukin-2 (CD25) in peripheral blood lymphocytes (PBL) of patients with gastric cancer. Methods CD25 percentages in PBL from 110 patients with gastric cancer and 100 normal individuals were examined by flow cytometry. Results were analyzed clinically and pathologically. Results Mean CD25% in PBL from normal individuals and patients with gastric cancer were 17.24±5.33 and 22.47±6.82, respectively, and the difference was significant (P<0.01). Abnormally elevated CD25% in PBL from patients with gastric cancer were correlated with tumor site, macropathology type, tumor size, differentiation degree and clinical stage. Conclusion Measuring CD25% in PBL from gastric cancer patients before surgery may provide a reference for diagnosis, immune treatment and judging prognosis.%目的了解胃癌患者外周血淋巴细胞(PBL)膜白细胞介素2受体(CD25）水平的临床意义。方法用流式细胞仪检测100例正常人和110例胃癌患者术前PBL中CD25%,并进行临床病理分析。结果正常人PBL中CD25%平均为17.24±5.33，110例胃癌病人PBL中CD25%平均为22.47±6.82, 差异有非常显著性(P<0.01)。胃癌患者PBL中CD25%升高与肿瘤发生部位、大体类型、肿瘤大小、分化程度和临床分期均有相关性。结论检测胃癌患者术前PBL中CD25%,可为临床提供病人诊断、免疫治疗及预后评估的参考依据。