Association Study of a Proliferation-inducing Ligand,Spermatogenesis Associated 8, Platelet-derived Growth Factor Receptor-alpha, and POLB Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population

摘要

Background:Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance.This study was conducted to examine whether the association of a proliferation-inducing ligand (APRIL),spermatogenesis associated 8 (SPATA8),platelet-derived growth factor receptor-alpha (PDGFRA),and DNA polymerase beta (POLB) with SLE can be replicated in a Chinese Han population.Methods:Chinese SLE patients (n =1247) and ethnically and geographically matched healthy controls (n =1440) were genotyped for the APRIL,SPATA8,PDGFRA,and POLB single-nucleotide polymorphisms (SNPs),rs3803800,rs8023715,rs1364989,and rs 12678588 using the Sequenom MassARRAY System.Results:The Chinese Han SLE patients and controls had statistically similar frequencies of alleles and genotypes of four gene polymorphisms.Moreover,no association signal was detected on different genetic models (additive,dominant,and recessive,all,P＞ 0.05) or in SLE subgroups stratified by various clinical manifestations (all,P ＞ 0.05).Conclusions:Different genetic backgrounds from different ancestries and various populations may result in different genetic risk factors for SLE.We did not detect any significant association with SNPs of APRIL,SPATA8,PDGFRA,and POLB.