• 主题
高级搜索  >
历史搜索 清空历史
您现在的位置：首页> 中文期刊>医药卫生>医药卫生总论>中华医学杂志（英文版）

中华医学杂志（英文版）

中华医学杂志（英文版）

CSCD

CSTPCD

Chinese Medical Journal
1887年创刊，中华医学会主办。中华医学杂志英文版(Chinese Medical Journal)是中华医学会会刊，是中国惟一被SCI核心版收录、具有百年以上历史的医学期刊。重点报道我国医学各学科最新进展和高水平科研成果，目前已被《科学引文索引（SCI）》、《医学索引（IM）》、Medline等国际著名检索系统收录。2009年SCI影响因子0.952，SCI被引频次3407。2010年被国际医学期刊编辑委员会（ICMJE）吸收为新成员。多次获得国家期刊奖、科协专项基金、自然基金等奖项和资助。实行全文上网 （www.cmj.org），网上投稿审稿(www.ecmj.org.cn)。
更多
  • 发文量：14355
  • 被引量：4876
  • H指数：2
  • 开始收录时间：
  • CNKI综合因子：
  • 维普期刊影响因子：
  • 万方期刊影响因子：
  • 创刊时间：
  • 国内刊号/CN：11-2154/R
    国际刊号/ISSN：0366-6999
  • 发行周期：半月刊
    邮发代号：2-920
  • 主管单位：中国科学技术协会
    主办单位：中华医学会
中华医学杂志（英文版）-联系信息
  • 主编：Chen Wang
  • 电话：010-51322059
  • 邮箱：office@cmaph.org
  • 地址：北京东四西大街四十二号
  • 邮编：100710
中华医学杂志（英文版）-获奖情况
  • • 卓越计划期刊
  • • 1992年分获国家三部委全国优秀科技期刊一等奖、中国科协优秀学术期 刊一等奖。1993年获中国科协全国优秀科技期刊奖。1997年获国家三部委第二届全国优秀科技期刊二等奖及中国科协优秀科技期刊一等奖。1997、1998、1999年连续3年获中国科协优秀期刊择优资助最高奖。1999年获得国家新闻出版署颁发的首届国家期刊奖和国家自然科学基金委员会期刊专项资助。2002年获第三届中国科协优秀科技期刊奖二等奖和专项经费资助以及国家期刊奖重点科技期刊奖。2003年以来多次获得中国科协和国家自然基金委的专项基金资助，以及中国科协的优秀论文奖。
  • 收录汇总
  • 刊内文献检索
  • 投稿信息

刊期浏览

相关中文期刊

相关中文会议

相关外文期刊

相关外文会议

最新期刊

热门期刊

中华医学杂志（英文版） >2021年第24期

学科

年度

全选（0）
排序：
共4384条结果
  • 摘要：Background:The accuracy of three-dimensional (3D) reconstructions from cone-beam computed tomography (CBCT) has been particularly important in dentistry,which will affect the effectiveness of diagnosis,treatment plan,and outcome in clinical practice.The aims of this study were to assess the linear,volumetric,and geometric accuracy of 3D reconstructions from CBCT and to investigate the influence of voxel size and CBCT system on the reconstructions results.Methods:Fifty teeth from 18 orthodontic patients were assigned to three groups as NewTom VG 0.15 mm group (NewTom VG;voxel size:0.15 mm;n =17),NewTom VG 0.30 mm group (NewTom VG;voxel size:0.30 mm;n =16),and VATECH DCTPRO 0.30 mm group (VATECH DCTPRO;voxel size:0.30 mm;n =17).The 3D reconstruction models of the teeth were segmented from CBCT data manually using Mimics 18.0 (Materialise Dental,Leuven,Belgium),and the extracted teeth were scanned by 3Shape optical scanner (3Shape A/S,Denmark).Linear and volumetric deviations were separately assessed by comparing the length and volume of the 3D reconstruction model with physical measurement by paired t-test.Geometric deviations were assessed by the root mean square value of the imposed 3D reconstruction and optical models by one-sample t-test.To assess the influence of voxel size and CBCT system on 3D reconstruction,analysis of variance (ANOVA) was used (α =0.05).Results:The linear,volumetric,and geometric deviations were-0.03 ± 0.48 mm,-5.4 ± 2.8％,and 0.117 ± 0.018 mm for NewTom VG 0.15 mm group;-0.45 ± 0.42 mm,-4.5 ± 3.4％,and 0.116 ± 0.014 mm for NewTom VG 0.30 mm group;and-0.93 ± 0.40 mm,-4.8 ± 5.1％,and 0.194 ± 0.117 mm for VATECH DCTPRO 0.30 mm group,respectively.There were statistically significant differences between groups in terms of linear measurement (P ＜ 0.001),but no significant difference in terms of volumetric measurement (P =0.774).No statistically significant difference were found on geometric measurement between NewTom VG 0.15 mm and NewTom VG 0.30 mm groups (P =0.999)while a significant difference was found between VATECH DCTPRO 0.30 mm and NewTom VG 0.30 mm groups (P =0.006).Conclusions:The 3D reconstruction from CBCT data can achieve a high linear,volumetric,and geometric accuracy.Increasing voxel resolution from 0.30 to 0.15 mm does not result in increased accuracy of 3D tooth reconstruction while different systems can affect the accuracy.
  • 摘要：Background:Many studies have reported that depression and anxiety have bidirectional relationship with headache.However,few researches investigated the roles of depression or anxiety in patients with headache.We surveyed the prevalence of depression and anxiety as a complication or cause of headache among outpatients with a chief complaint of headache at neurology clinics in general hospitals.Additional risk factors for depression and anxiety were also analyzed.Methods:A cross-sectional study was conducted at 11 general neurological clinics.All consecutive patients with a chief complaint of headache were enrolled.Diagnoses of depression and anxiety were made using the Chinese version of the Mini International Neuropsychiatric Interview,and those for headache were made according to the International Classification of Headache Disorders,2nd Edition.The headache impact test and an 11-point verbal rating scale were applied to assess headache severity and intensity.Logistic regression was used to analyze risk factors of patients with headache for depression or anxiety.Results:A total of 749 outpatients with headache were included.Among them,148 (19.7％) were diagnosed with depression and 103 (13.7％) with anxiety.Further analysis showed that 114 (15.2％) patients complaining headache due to somatic symptoms of psychiatric disorders and 82 (10.9％) had a depression or anxiety comorbidity with headache.Most patients with depression or anxiety manifested mild to moderate headaches.Poor sleep and severe headache-related disabilities were predictors for either depression or anxiety.Conclusion:Clinicians must identify the etiology of headache and recognize the effects of depression or anxiety on headache to develop specific treatments.
  • 摘要：Background:Brain acid soluble protein 1 (BASP1) is identified as a novel potential tumor suppressor in several cancers.However,its role in thyroid cancer has not been investigated yet.In the present study,the antitumor activities of BASP1 against the growth and migration of thyroid cancer cells were evaluated.Methods:BASP1 expression in thyroid cancer tissues and normal tissues were examined by immunohistochemical staining and the association between its expression and prognosis was analyzed,pcDNA-BASP 1 carrying full length ofBASP1 cDNA was constructed to restore the expression ofBASP 1 in thyroid cancer cell lines (BHT-101 and KMH-2).The cell proliferation in vitro and in vivo was evaluated by WST-1 assay and xenograft tumor models,respectively.Cell cycle distribution after transfection was analyzed using flow cytometry.Cell apoptosis after transfection was examined by annexin V/propidium iodide assay.The migration was examined using transwell assay.Results:BASP 1 expression was abundant in normal tissues while it is significantly decreased in cancer tissues (P =0.000).pcDNA-BASP1 restored the expression of BASP1 and significantly inhibited the growth of BHT-101 and KMH-2 cells as well as xenograft tumors in nude mice (P =0.000).pcDNA-BASP1 induced G1 arrest and apoptosis in BHT-101 and KMH-2 cells.In addition,pcDNA-BASP1 significantly inhibited the cell migration.Conclusions:Downregnlation of BASP1 expression may play a role in the tumorigenesis of thyroid cancer.Restoration of BASP1 expression exerted extensive antitumor activities against growth and migration of thyroid cancer cells,which suggested that BASP1 gene might act as a potential therapeutic agent for the treatment of thyroid cancer.
  • 摘要：Background:The functional improvement following bone marrow stromal cells (BMSCs) transplantation after stroke is directly related to the number of engrafted cells and neurogenesis in the injured brain.Here,we tried to evaluate whether 3-methyl-l-phenyl-2-pyrazolin-5-one (MCI-186),a free radical scavenger,might influence BMSCs migration to ischemic brain,which could promote neurogenesis and thereby enhance treatment effects after stroke.Methods:Rat transient middle cerebral artery occlusion (MCAO) model was established.Two separate MCAO groups were administered with either MCI-186 or phosphate-buffered saline (PBS) solution to evaluate the expression of stromal cell-derived factor-1 (SDF-1) in ischemic brain,and compared to that in sham group (n =5/group/time point[at 1,3,and 7 days after operation]).The content ofchemokine receptor-4 (CXCR4,a main receptor of SDF-1) at 7 days after operation was also observed on cultured BMSCs.Another four MCAO groups were intravenously administered with either PBS,MCI-186,BMSCs (2 x 106),or a combination of MCI-186 and BMSCs (n =10/group).5-bromo-2-deoxyuridine (BrdU) and Nestin double-immunofluorescence staining was performed to identify the engrafted BMSCs and neuronal differentiation.Adhesive-removal test and foot-fault evaluation were used to test the neurological outcome.Results:MCI-186 upregulated the expression ofSDF-1 in ischemic brain and CXCR4 content in BMSCs was enhanced after hypoxic stimulation.When MCAO rats were treated with either MCI-186,BMSCs,or a combination ofMCI-186 and BMSCs,the neurologic function was obviously recovered as compared to PBS control group (P ＜ 0.01 or 0.05,respectively).Combination therapy represented a further restoration,increased the number of BMSCs and Nestin+ cells in ischemic brain as compared with BMSCs monotherapy (P ＜ 0.01).The number ofengrafted-BMSCs was correlated with the density of neuronal cells in ischemic brain (r =0.72,P ＜ 0.01) and the improvement of foot-fault (r =0.70,P ＜ 0.01).Conclusion:MCI-186 might promote BMSCs migration to the ischemic brain,amplify the neurogenesis,and improve the effects of cell therapy.
  • 摘要：Background:Tetracycline (TET) has been found to have both antibiotic and anti-inflammatory properties.The anti-inflammatory effect of topical TET on atopic dermatitis (AD) has not been reported.The purpose of this study was to explore the potential role of topical TET and its anti-inflammatory effects in a mouse model of AD.Methods:The 2％ TET was applied topically to ears of MC903-induced AD-like BALB/c mice once a day.AD-like symptoms and severity were evaluated by assessing skin scoring of dermatitis,ear thickness,and frequency of scratching.Serum IgE and thymic stromal lymphopoietin (TSLP) levels were measured by enzyme-linked immunosorbent assay.Western blot was used for analyzing the expressions of TSLP,protease-activated receptor 2 (PAR2),and nuclear factor-kappa B (NF-κB) in skin lesions.Real-time polymerase chain reaction was performed to assess the mRNA levels of TSLP and inflammatory cytokines including interleukin (IL)-4,IL-13,tumor necrosis factor (TNF)-α,and IL-1β in skin lesions.Results:Scoring of dermatitis (9.00 ± 0.63 vs.6.67 ± 1.03,P =0.001),ear thickness (0.44 ± 0.02 mm vs.0.40 ± 0.03 mm,P =0.018),and serum IgE level (421.06 ± 212.13 pg/ml vs.244.15 ± 121.39 pg/ml,P =0.047) were all improved in the 2％ TET treatment group compared with AD group.Topical TET significantly reduced the serum level of TSLP (119.04 ± 38.92 pg/ml vs.65.95 ± 54.61 pg/ml,P =0.011) and both mRNA and protein expressions of TSLP in skin lesions compared with AD group (P =0.003 and 0.011,respectively),and NF-κB and PAR2 expression in skin lesions were also suppressed (P =0.016 and 0.040,respectively).Furthermore,expressions of inflammatory cytokines IL-4,IL-13,and TNF-α in skin lesions were down-regulated in 2％ TET group compared with AD group (P =0.035,0.008,and 0.044,respectively).Conclusions:Topical TET exerted anti-inflammatory effects through suppression of TSLP and inflammatory cytokines in AD mouse model,suggesting TET as a potential agent for the topical treatment of AD in the future.
  • 摘要：Background:Previous studies showed that patients with cardiogenic shock (CS) from ST-elevation acute myocardial infarction (STEMI) supported by intra-aortic balloon pump (IABP) before primary percutaneous coronary intervention (PCI) decreased the risk of in-hospital mortality than patients who received IABP after PCI.However,little evidence is available on the optimal order of IABP insertion and primary PCI.The aim of this study was to investigate the impact of the sequence of IABP support and PCI and its association with major adverse cardiac and cerebrovascular events (MACCEs).Methods:Data were obtained from 218 consecutive patients with CS due to STEMI in Beijing Anzhen Hospital between 2008 and 2014,who were treated with IABP and PCI.The patients were divided into two groups:Group A in whom IABP received before PCI (n =106)and Group B in whom IABP received after PCI (n =112).We evaluated the myocardial perfusion using myocardial blush grade and resolution of ST-segment elevation.The primary endpoint was 12-month risk of MACCE.Results:Most baseline characteristics were similar in patients between the two groups.However,patients received IABP before PCI were associated with a delay of door-to-balloon time (DBT) and higher troponin Ⅰ level (P ＜ 0.05).However,myocardial perfusion was significantly improved in patients treated with IABP before PCI (P ＜ 0.05).Overall,IABP support before PCI was not associated with significantly lower risk of MACCE (P ＞ 0.05).In addition,risk of all-cause mortality,bleeding,and acute kidney injury (AKI)was similar between two groups (P ＞ 0.05).Multivariate analysis showed that DBT (odds ratio [OR] 2.5,95％ confidence interval [CI]1.1-4.8,P=0.04),IABP support after PCI (OR 5.7,95％ CI 2.7-8.4,P=0.01),and AKI (OR 7.4,95％ CI 4.9-10.8,P=0.01) were the independent predictors of mortality at 12-month follow-up.Conclusions:Early IABP insertion before primary PCI is associated with improved myocardial perfusion although DBT increases.IABP support before PCI does not confer a 12-month clinical benefit when used for STEMI with CS.
  • 摘要：Background:Image-guided radiation therapy (IGRT) is the preferred method for curative treatment of localized prostate cancer,which could improve disease outcome and reduce normal tissue toxicity reaction.IGRT using cone-beam computed tomography (CBCT) in combination with volumetric-modulated arc therapy (VMAT) potentially allows smaller treatment margins and dose escalation to the prostate.The aim of this study was to compare the difference of dosimetric diffusion in conventional IGRT using 7-field,step-and-shoot intensity-modulated radiation therapy (IMRT) and hypofractionated IGRT using VMAT for patients with localized prostate cancer.Methods:We studied 24 patients who received 78 Gy in 39 daily fractions or 70 Gy in 28 daily fractions to their prostate with/without the seminal vesicles using IMRT (n =12) or VMAT (n =12) for prostate cancer between November 2013 and October 2015.Image guidance was performed using kilovoltage CBCT scans equipped on the linear accelerator.Offline planning was performed using the daily treatment images registered with simulation computed tomography (CT) images.A total of 212 IMRT plans in conventional cohort and 292 VMAT plans in hypofractionated cohort were enrolled in the study.Dose distributions were recalculated on CBCT images registered with the planning CT scanner.Results:Compared with 7-field,step-and-shoot IMRT,VMAT plans resulted in improved planning target volume (PTV) D95％ (7663.17 ± 69.57 cGy vs.7789.17 ± 131.76 cGy,P ＜ 0.001).VMAT reduced the rectal D25 (P ＜ 0.001),D35 (P ＜ 0.001),and D50 (P ＜ 0.001),bladder V50 (P ＜ 0.001),D25 (P =0.002),D35 (P =0.028),and D50 (P =0.029).However,VMAT did not statistically significantly reduce the rectal V50,compared with 7-field,step-and-shoot IMRT (25.02 ± 5.54％ vs.27.43 ± 8.79％,P =0.087).Conclusions:To deliver the hypofractionated radiotherapy in prostate cancer,VMAT significantly increased PTV D95％ dose and decreased the dose of radiation delivered to adjacent normal tissues comparing to 7-field,step-and-shoot IMRT.Daily online image-guidance and better management of bladder and rectum could make a more precise treatment delivery.
  • 摘要：Background:The antagonistic actions of anticholinesterase drugs on non-depolarizing muscle relaxants are theoretically related to the activity ofacetylcholinesterase (AChE) in the neuromuscular junction (NMJ).However,till date the changes of AChE activity in the NMJ during sepsis have not been directly investigated.We aimed to investigate the effects of sepsis on the antagonistic actions ofneostigmine on rocuronium (Roc) and the underlying changes of AChE activity in the NMJ in a rat model of cecal ligation and puncture (CLP).Methods:A total of 28 male adult Sprague-Dawley rats were randomized to undergo a sham surgery (the sham group,n =12) or CLP (the septic group,n =16).After 24 h,the time-response curves of the antagonistic actions of 0.1 or 0.5 μmol/L of neostigmine on Roc (10 μmol/L)-depressed diaphragm twitch tension were measured.Meanwhile,the activity of AChE in the NMJ was detected using a modified Karnovsky and Roots method.The mRNA levels of the primary transcript and the type T transcript of AChE (AChET) in the diaphragm were determined by real-time reverse transcription-polymerase chain reaction.Results:Four of 16 rats in the septic group died within 24 h.The time-response curves of both two concentrations ofneostigmine in the septic group showed significant upward shifts from those in the sham group (P ＜ 0.001 for 0.1 μmol/L;P =0.009 for 0.5 μmol/L).Meanwhile,the average optical density of AChE in the NMJ in the septic group was significantly lower than that in the sham group (0.517 ± 0.045 vs.1.047 ± 0.087,P ＜ 0.001).The AChE and AChET mRNA expression levels in the septic group were significantly lower than those in the sham group (P =0.002 for AChE;P =0.00l for AChET).Conclusions:Sepsis strengthened the antagonistic actions ofneostigmine on Roc-depressed twitch tension of the diaphragm by inhibiting the activity of AChE in the NMJ.The reduced content of AChE might be one of the possible causes of the decreased AChE activity in the NMJ.
  • 摘要：Objective:To systematically summary the updated results about the pathogenesis of Hirschsprung's-associated enterocolitis (HAEC).Besides,we discussed the research key and direction based on these results.Data Sources:Our data cited in this review were obtained mainly from PubMed from 1975 to 2015,with keywords "Hirschsprungenterocolitis","Hirschsprung's enterocolitis","Hirschsprung's-associated enterocolitis","Hirschsprung-associated enterocolitis","HAEC",and "EC".Study Selection:Articles regarding the pathogenesis of HAEC were selected,and the articles mainly regarding the diagnosis,surgical approach,treatment,and follow-up were excluded.Results:Several factors,mainly including mucus barrier,intestinal microbiota,and immune function,as well as some other factors such as genetic variations and surgical reasons,have been found to be related to the pathogenesis of HAEC.Changed quantity and barrier property of mucus,different composition of microbiota,and an abnormal immtme state work together or separately trigger HAEC.Conclusions:The maintenance of intestinal homeostasis is due to a well cooperation of microbiota,mucus barrier,and immune system.If any part presents abnormal,intestinal homeostasis will be broken.Meanwhile,for patients with Hirschsprung's disease or HAEC,dysfunction of these parts has been found.Thus,the happening of HAEC may be mainly attributed to the disorders of intestinal microbiota,mucus barrier,and immune system.
  • 摘要：Background:Apoptosis of endothelial cells (ECs) plays a key role in the development of atherosclerosis and there are also evidence indicated that phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a viable target in therapeutic approaches to prevent vascular ECs apoptosis.Aberrant miR-106b-5p expression has been reported in the plasma of patients with unstable atherosclerotic plaques.However,the role and underlying mechanism of miR-106-5p in the genesis of atherosclerosis have not been addressed.In this study,we explored the anti-apoptotic role of miR-106-5p by regulating PTEN expression in vascular ECs.Methods:Real-time reverse transcription polymerase chain reaction (RT-PCR) was performed to detect the expression levels of miR-106b-5p in human atherosclerotic plaques and normal vascular tissues.Human umbilical vein endothelial cells (HUVEC) were transfected with miR-106b-5p mimic or negative control mimic,and apoptosis was induced by serum starvation and tumor necrosis factor-α (TNF-α) treat.Western blotting and real-time RT-PCR experiments were used to detect PTEN expression levels and TNF-α-induced apoptosis was evaluated by the activation of caspase-3 and cell DNA fragmentation levels in HUVEC.Results:The expression of miR-106b-5p was significantly downregulated in plaques than in normal vascular tissues.TNF-α significantly downregulated miR-106b-5p expression levels and upregulated activation of caspase-3 and cell DNA fragmentation levels in HUVEC.Overexpression ofmiR-106b-5p with miR-106b-5p mimic inhibited PTEN expression and TNF-α-induced apoptosis in HUVEC.Luciferase reporter assays confirmed that miR-106b-5p binds to PTEN mRNA 3' untranslated region site.Conclusion:MiR-106b-5p could inhibit the expression of PTEN in vascular ECs,which could block TNF-α-induced activation of caspase-3,thus prevent ECs apoptosis in atherosclerosis diseases.
  • 摘要：Background:Keams-Sayre syndrome (KSS) is a mitochondrial DNA (mtDNA) deletion disorder characterized by a triad of onset before 20 years of age,ophthalmoplegia,and pigmentary retinopathy.The heart and central nervous system are commonly involved.We summarized clinical and brain magnetic resonance imaging (MRI) features of a cohort of Chinese KSS patients.Methods:Nineteen patients confirmed by muscle biopsy and mtDNA analysis were enrolled.We examined clinical profiles,mainly focusing on changes in electrocardiogram (ECG) and brain MRI.The correlation between genotype and phenotype was statistically analyzed.Results:The mean age of onset was 9.6 ± 4.3 years,with all developing the classic triad at the time of diagnosis.Heart conduction block was detected in 63.2％,with four initially presenting as bundle branch block and developing into complete atrioventricular block over 3-72 months.Brain MRI showed symmetric high-T2 signals in 100％ of cerebral and cerebellar white matter,as well as brainstem,46.7％ of basal ganglia,and 53.3％ of thalamus.There were two patterns of cerebral white matter involvements,one with selective subcortical U-fibers and the other with periventricular white matter.The size of mtDNA deletion did not significantly correlate with age of onset or percentage of ragged blue fibers on muscle pathology.Conclusions:The clinical features of KSS evolve dynamically,affecting the cardiac conduction system predominantly,highlighting the significance of ECG monitoring.Brain MRI showed changes involving both the white matter and deep gray nuclei.Clinical presentation or severity of muscle pathological changes is not related to the size of mtDNA deletions.
  • 摘要：Background:Early embryonic developmental arrest is the most commonly understudied adverse outcome of pregnancy.The relevance of intrauterine infection to spontaneous embryonic death is rarely studied and remains unclear.This study aimed to investigate the relationship between intrauterine bacterial infection and early embryonic developmental arrest.Methods:Embryonic chorion tissue and uterine swabs for bacterial detection were obtained from 33 patients who underwent artificial abortion (control group) and from 45 patients who displayed early embryonic developmental arrest (trial group).Results:Intrauterine bacterial infection was discovered in both groups.The infection rate was 24.44％ (11/45) in the early embryonic developmental arrest group and 9.09％ (3/33) in the artificial abortion group.Classification analysis revealed that the highest detection rate for Micrococcus luteus in the early embryonic developmental arrest group was 13.33％ (6/45),and none was detected in the artificial abortion group.M.luteus infection was significantly different between the groups (P ＜ 0.05 as shown by Fisher's exact test).In addition,no correlation was found between intrauterine bacterial infection and history of early embryonic developmental arrest.Conclusions:M.luteus infection is related to early embryonic developmental arrest and might be one of its causative factors.
  • 摘要：Background:Aldehyde dehydrogenase 2 (ALDH2) is involved in the pathophysiological processes of cardiovascular diseases.Recent studies showed that mutant ALDH2 could increase oxidative stress and is a susceptible factor for hypertension.In addition,wild-typeALDH2could improve the endothelial functions,therefore reducing the risk of developing atherosclerosis.The aim of the present study was to explore the frequency of the Glu504Lys polymorphism of the ALDH2 gene and its relation to carotid intima-media thickness (CIMT) in a group of patients with essential hypertension (EH) and to investigate the association between the Glu504Lys polymorphism and CIMTin Chinese Han patients with EH.Methods:In this study,410 Chinese Han patients with EH who received physical examinations at the People's Hospital of Sichuan Province (China) were selected.DNA microarray chip was used for the genotyping of the Glu504Lys polymorphism of the ALDH2 gene.The differences in CIMT among patients with different Glu504Lys ALDH2 genotypes were analyzed.Results:The mean CIMT of the patients carrying AA/AG and GG genotypes was 1.02 ± 0.31 mm and 0.78 ± 0.28 mm,respectively.One-way ANOVA showed that the CIMT of the patients carrying the AA/AG genotype was significantly higher than in the ones carrying the GG genotype (P ＜ 0.001).Multivariate logistic regression showed that the Glu504Lys AA/AG genotype of the ALDH2 gene was one of the major factors influencing the CIMT in patients with EH (odds ratio =3.731,95％ confidence interval =1.589-8.124,P =0.001).Conclusions:The Glu504Lys polymorphism of the ALDH2 gene is associated with the CIMT of Chinese Han patients with EH in Sichuan,China.
  • 摘要：Background:Lipid storage myopathy (LSM) is a genetically heterogeneous group with variable clinical phenotypes.Late-onset multiple acyl-coenzyme A dehydrogenation deficiency (MADD) is a rather common form of LSM in China.Diagnosis and clinical management of it remain challenging,especially without robust muscle biopsy result and genetic detection.As the noninvasion and convenience,muscle magnetic resonance imaging (MRI) is a helpful assistant,diagnostic tool for neuromuscular disorders.However,the disease-specific MRI patterns of muscle involved and its diagnostic value in late-onset MADD have not been systematic analyzed.Methods:We assessed the MRI pattern and fat infiltration degree of the lower limb muscles in 28 late-onset MADD patients,combined with detailed clinical features and gene spectrum.Fat infiltration degree of the thigh muscle was scored while that ofgluteus was described as obvious or not.Associated muscular atrophy was defined as obvious muscle bulk reduction.Results:The mean scores were significantly different among the anterior,medial,and posterior thigh muscle groups.The mean of fat infiltration scores on posterior thigh muscle group was significantly higher than either anterior or medial thigh muscle group (P ＜ 0.001).Moreover,the mean score on medial thigh muscle group was significantly higher than that of anterior thigh muscle group (P ＜ 0.01).About half of the patients displayed fat infiltration and atrophy in gluteus muscles.Of 28 patients,12 exhibited atrophy in medial and/or posterior thigh muscle groups,especially in posterior thigh muscle group.Muscle edema pattern was not found in all the patients.Conclusions:Late-onset MADD patients show a typical muscular imaging pattern of fat infiltration and atrophy on anterior,posterior,and medial thigh muscle groups,with major involvement of posterior thigh muscle group and gluteus muscles and a sparing involvement of anterior thigh compartment.Our findings also suggest that muscle MRI of lower limbs is a helpful tool in guiding clinical evaluation on late-onset MADD.
  • 摘要：Background:Liquid-based cytology (LBC) offers an altemative method to biopsy in screening endometrial cancer.Cell block (CB),prepared by collecting residual cytological specimen,represents a novel method to supplement the diagnosis of endometrial cytology.This study aimed to compare the specimen adequacy and diagnostic accuracy of LBC and CB in the diagnosis of endometrial lesions.Methods:A total of 198 women with high risks of endometrial carcinoma (EC) from May 2014 to April 2015 were enrolled in this study.The cytological specimens were collected by the endometrial sampler (SAP-1) followed by histopathologic evaluation of dilatation and curettage or biopsy guided by hysteroscopy.The residual cytological specimens were processed into paraffin-embedded CB after LBC preparation.Diagnostic accuracies of LBC and CB for detecting endometrial lesions were correlated with histological diagnoses.Chi-square test was used to compare the specimen adequacies of LBC and CB.Results:The specimen inadequate rate of CB was significantly higher than that of LBC (22.2％ versus 7.1％,P ＜ 0.01).There were 144 cases with adequate specimens for LBC and CB preparation.Among them,29 cases were atypical endometrial hyperplasia (11 cases) or carcinoma (18 cases) confirmed by histology evaluation.Taking atypical hyperplasia and carcinoma as positive,the diagnostic accuracy of CB was 95.1％ while it was 93.8％ in LBC.When combined LBC with CB,the diagnostic accuracy was improved to 95.8％,with a sensitivity of 89.7％ and specificity of 97.4％.Conclusions:CB is a feasible and reproducible adjuvant method for screening endometrial lesions.A combination of CB and LBC can improve the diagnostic accuracy of endometrial lesions.
  • 摘要：Background:Human rhinoviruses (HRVs) are divided into three genetic species:HRV-A,HRV-B,and HRV-C.The association of different HRV species with asthma in children in China has not yet been evaluated.This preliminary study aimed to assess the associations between different HRV species,particularly HRV-C,and asthma in young children in China.Methods:A total of 702 nasopharyngeal aspirates were obtained from 155 children with asthma (asthma group),461 children with acute respiratory infection (ARI) without asthma (nonasthma ARI group),and 86 children from the control group.Semi-nested polymerase chain reaction (PCR) was used to detect HRVs,and PCR products were sequenced for species identification.Epidemiological characteristics of HRV-positive cases were analyzed.Results:HRVs were the most common pathogen (15.4％;108/702) in the patients in this study.The prevalence of HRV was significantly different (F =20.633,P =0.000) between the asthma (25.8％) and nonasthma ARI groups (11.1％).Phylogenetic analysis indicated that in the 108 cases positive for HRVs,41 were identified as HRV-A,8 as HRV-B,and 56 as HRV-C.Comparing the asthma with the nonasthma ARI group,Spearman's rank correlation analysis revealed an association between HRV-A (P ＜ 0.05) and C (P ＜ 0.01) and asthma,confirmed by regression analysis,with odds ratios of 2.2 (HRV-A) and 4.2 (HRV-C).Conclusions:Our data revealed a high prevalence of HRVs in children in China,regardless of clinical status.HRV-C was the dominant species and may be one of the key factors in the association of HRVs with asthma.
  • 摘要：Background:Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic disease that can involve multiple organs and various clinical phenotypes.The purpose of this study was to analyze different types of organ involvement in IgG4-RD patients in China.Methods:We conducted a prospective cohort study on IgG4-RD patients to analyze the clinical manifestations and rare features of IgG4-RD.Patients were grouped into different types according to organ involvement regarding organ number and organ site.The constituent ratio in different types was also analyzed.Results:A total of 200 IgG4-RD patients,with a male:female ratio of 2.08:1,were grouped into different types.Cases having involvement of two or three organs were the most common whereas the fewest number of patients had multi-organ (≥4) involvement.Serum IgG4 and IgE levels,IgG4/IgG ratio,and percentage of eosinophils increased as the number of involved organs increased.In addition,constituent ratio analysis revealed that patients with salivary gland/lacrimal gland swelling,who also constituted the largest number of IgG4-RD patients,had higher serum IgG4 concentrations and IgG4/IgG values,had higher percentage of Eos,and were more likely to have had a history of allergies relative to patients with internal organ involvement.Conclusions:The characteristic feature of IgG4-RD is multiple organ involvement with various clinical manifestations and different types.Although serum IgG4 levels increased with the number of involved organs,serum IgG4 levels were higher for those patients with salivary gland/lacrimal gland swelling compared with those with intemal organ involvement.Thus,valuable clues to the differential diagnosis of IgG4-RD could be obtained by examining the clinical patterns of organ involvement.
  • 摘要：Background:Various surgical approaches for the removal of sellar region lesions have previously been described.This study aimed to evaluate the reliability and safety of the frontolateral approach (FLA) to remove sellar region lesions.Methods:We presented a retrospective study of 79 patients with sellar region lesions who were admitted and operated by the FLA approach from August 2011 to August 2015 in Department of Neurosurgery of Beijing Tian Tan Hospital.We classified FLA into three types,compared the FLA types to the areas of lesion invasion,and analyzed operation bleeding volume,gross total resection (GTR) rate,visual outcome,and mortality.Results:Seventy-nine patients were followed up from 2.9 to 50.3 months with a mean follow-up of 20.5 months.There were 42 cases of meningiomas,25 cases of craniopharyngiomas,and 12 cases of pituitary adenomas.The mean follow-up Karnofsky Performance Scale was 90.4.GTR was achieved in 75 patients (94.9％).Two patients (2.5％) had tumor recurrence.No patients died perioperatively or during short-term follow-up.Three patients (3.8％) with craniopharyngioma died 10,12,and 23 months,respectively,after surgery.The operative bleeding volume of this study was no more than that of the other approaches in the sellar region (P =0.783).In this study,35 patients (44.3％) had visual improvement after surgery,38 patients (48.1％) remained unchanged,and three patients' visual outcome (3.8％) worsened.Conclusions:FLA was an effective approach in the treatment of sellar region lesions with good preservation of visual function.FLA classification enabled tailored craniotomies for each patient according to the anatomic site of tumor invasion.This study found that FLA had similar outcomes to other surgical approaches of sellar region lesions.
  • 摘要：Background:Some ultrasonographic (US) signs overlap between benign and malignant nodules.The purpose of this study was to raise a special US sign of benign thyroid nodules,termed the "onion skin-liked sign."Methods:Twenty-seven patients with 27 nodules who shrank naturally and the "onion skin-liked sign" appeared on the final US images were enrolled in the study.The ultrasound characters and risk stratifications at the start and end of observation were compared.Then,thirty goiters with fibrosis and thirty papillary thyroid carcinomas (PTC) were randomly selected from the database of our hospital,matched the sizes of 27 nodules at the end point of observation.The differences of "onion skin-liked sign" between the two groups were analyzed.Results:The average duration of follow-up of 27 nodules was 24.0 ± 12.2 months (range,12-65 months).At the end of the follow-up,the size of the nodules decreased on average by 1.26 ± 0.82 cm (range,0.3-3.4 cm) and calcification was found in 21 nodules,compared with only 2 nodules with calcification at the start of the follow-up.In addition,only negligible or no blood flow signal could be detected at the periphery of all the nodules and 100％ (27/27) were high suspicion at the end of observation.In matched groups,all PTC showed high suspicion of malignancy,18/30 (60％) goiters with fibrosis were high suspicion and 11/30 (37％) were intermediate suspicion.Twenty-two patients in the group of nodular fibrosis presented"onion skin-liked sign," which was not shown in any patient of PTC group.The sensitivity,specificity,positive predictive value,and negative predictive value of"onion skin-liked sign" in predicting nodular goiter with fibrosis were 73.3％,100％,100％,and 78.9％,respectively.Conclusions:The "onion skin-liked sign" was a characteristic US feature of benign thyroid nodules detected in the follow-up of thyroid nodules.It is useful to differentiate PTCs and nodular goiters with fibrosis.
  • 摘要：Background:Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by recurrent episodes of hypersomnia.Polysomnographic (PSG) researches of KLS have been reported only in few publications in the past decades.This study aimed to investigate the characteristics of PSG of KLS.Methods:This study,which was conducted from March 2010 to July 2014,included seven patients diagnosed with KLS in the Sleep and Wake Disorder Center of Huashan Hospital,Fudan University (Shanghai,China).PSG and multiple sleep latency tests (MSLT) were performed during their episodes and the results were evaluated.Results:Five of the seven patients were males.The mean age at KLS onset was 15.6 ± 3.6 years.The number of episodes ranged from 2 to 7.The duration of episodes lasted from 4 to 11 days.The sleep architecture and proportion were normal in most of the patients.The average value of mean sleep latency was 6.9 ± 4.1 min.No sleep-onset rapid eye movement (SOREM) was detected in three of the patients,whereas one patient experienced one period of SOREM,and such episodes occurred twice in other two patients.Conclusions:We found that sleep architecture and proportion were normal in most KLS patients.However,the results of PSG and MSLT had no specificity for KLS patients.
  • 摘要：Background:The accurate measurement of the femoral anteversion (FA) angle is always a topic of much debate in the orthopedic surgery and radiology research.We aimed to explore a new FA measurement method to acquire accurate results without radiation damage using piglet model.Methods:A total of thirty piglets were assigned to two groups based on the age.Bilateral femora were imaged with 3.0-T magnetic resonance (MR) and 64-slice computed tomography (CT) examinations on all piglets.FA was measured on MR-three-dimensional (3D) postprocessing software with a four-step method:initial validation of the femoral condylar axis,validation of the condylar plane,validation of the femoral neck axis,and line-plane angle measurement of FA.After MR and CT examinations,all piglets were sacrificed and their degree of FA was measured using their excised,dried femora.MR,CT,and dried-femur measurement results were analyzed statistically;MR and CT measurements were compared for accuracy against each other and against the gold standard dried femur measurement.Results:In both groups,the mean FA value measured by MR was lower than that measured by CT.A statistically significant difference was observed between CT-and dried-femur measurements but not between MR-and dried-femur measurements.A higher correlation (0.783 vs.0.408) and a higher consistency (0.863 vs.0.578) with dried-femur measurement results were seen for MR measurements than CT measurements in the 1-week age group.However,in the 8-week age group,similar correlations (0.707 vs.0.669) and consistencies (0.864 vs.0.821) were observed.Conclusions:Noninvasive MR-3D-Cube reconstruction was able to accurately measure FA in piglets.Particularly in the 1-week age group with a larger proportion of cartilaginous structures,the correlation and consistency between MR-and dried-femur measurement results were higher than those between CT-and dried-femur measurements,suggesting that MR may be a new useful examination tool for FA-related diseases in children.

    中华医学杂志（英文版）的期刊信息

    • 曾用名：
    • 创刊时间：
    • 地区：
    • 语言：中文
    • 热门主题：中华医学会
    • 学科分类：

    中华医学杂志（英文版）的获奖情况

    • • 卓越计划期刊
    • • 1992年分获国家三部委全国优秀科技期刊一等奖、中国科协优秀学术期 刊一等奖。1993年获中国科协全国优秀科技期刊奖。1997年获国家三部委第二届全国优秀科技期刊二等奖及中国科协优秀科技期刊一等奖。1997、1998、1999年连续3年获中国科协优秀期刊择优资助最高奖。1999年获得国家新闻出版署颁发的首届国家期刊奖和国家自然科学基金委员会期刊专项资助。2002年获第三届中国科协优秀科技期刊奖二等奖和专项经费资助以及国家期刊奖重点科技期刊奖。2003年以来多次获得中国科协和国家自然基金委的专项基金资助，以及中国科协的优秀论文奖。

    中华医学杂志（英文版）的收录情况

    • • 农业与生物科学研究中心文摘
    • • 化学文摘（网络版）
    • • 中国科学引文数据库（2011-2012）
    • • 中国科学引文数据库（2013-2014）
    • • 中国科学引文数据库（2015-2016）
    • • 中国科学引文数据库（2017-2018）
    • • 中国科学引文数据库（2019-2020）
    • • 开放获取期刊指南
    • • 医学文摘
    • • 哥白尼索引
    • • 日本科学技术振兴机构数据库
    • • 生物医学检索系统
    • • 科学引文索引（扩展库）
    • • 文摘与引文数据库
    • • 中国科技核心期刊

    中华医学杂志（英文版）的投稿信息

    • 投稿方式：
    • 投稿须知：点击查看
    • 期刊官方网站：点击前往
    • 版面费：
    • 审稿费：元
    • 通讯地址：北京东四西大街四十二号
    • 邮编：100710
    • 联系电话：010-51322059
    • 邮箱：office@cmaph.org
    • 期刊栏目：
    免费订阅本刊

    客服邮箱：kefu@zhangqiaokeyan.com

    京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有 出版物经营许可证

    • 客服微信

    • 服务号