制备医用生物补片材料装置的改进

摘要

目的:对制备医用生物补片装置进行改进,使该类材料的制备可以实现规模化、自动化.方法:通过综合分析原材料特点及各制备工艺流程步骤,对该装置的摇床进行改进,加装筒状处理系统.筒内设计动物膜材料的铺平固定装置,顶部和底部设计进液口和出液口,整个系统固定在摇床底座上.结果:使用该装置后,制备效率显著提升,原料利用率提高了20％,产品合格率提升了35％,制备周期缩短了33％,总体成本节约了40％.结论:该装置能够满足多种动物源材料的制备需求,制备工艺简单、批间差异小,原料利用率和产品合格率均有大幅度提升,降低了医用生物补片的生产成本,促进了医用生物补片在临床上的应用.%Objective To modify the existing preparation instrument for medical patch material to realize its scale and automatic production.Methods The instrument had its shaking table improved and a cylindrical processing system added with comprehensive analysis on raw materials and kinds of process flows.A spreading and fixation mechanism for animal materials was placed in the cylindrical processing system,which had the holes for liquid inlet and outlet respectively on its top and bottom.The cylindrical processing system was fixed to the base of the shaking table.Results The instrument enhanced preparation efficiency significantly,and had the raw material utilization rate increased by 20％,product qualification rate raised by 35％,preparation cycle reduced by 33％ and total cost saved by 40％.Conclusion The instrument behaves well in adaptability to multi animals,preparation process,inter-assay difference,raw material utilization rate,product qualification rate and cost reduction,which is of great significance to promote the clinical application of medical biological patch.