Objective To study the changes and clinical significance of adiponectin (ADP), 25(OH) D3 and resistin in gestational diabetes mellitus ( GDM) .Methods Blood specimens at gestational age of 11 -14 weeks were collected from 2 000 pregnant women receiving antenatal examination in obstetric clinic of the Fourth Hospital of Shijiazhuang from January 2013 to January 2014.All pregnant women received OGTT test at 24 to 28 weeks, and 86 cases diagnosed with GDM were selected as research objects.Another 75 cases of healthy pregnant women examined at the same period were selected as controls.ADP, 25(OH)D3 and resistin levels at three trimesters of pregnancy were observed dynamically.Results The incidence of GDM was 4.3%(86/2 000) .With the progress of pregnancy, ADP and 25( OH) D3 at second and third trimester in both groups decreased significantly ( ADP: F value was 43.3 and 187.9, respectively;25(OH)D3:F value was 8.7 and 9.3, respectively, all P<0.05).Compared with the control group, the levels of ADP and 25(OH)D3 at three trimesters of pregnancy were significantly reduced in GDM group ( ADP:t value was 5.0, 13.4 and 14.1, respectively;25(OH)D3:t value was 2.5, 2.1 and 2.2, respectively, all P<0.05).Resistin in middle and late pregnancy increased compared with that in early pregnancy in both groups (F value was 149.3 and 56.0, respectively, both P<0.05), and the increase in GDM group was more significant (t value was 15.8, 15.4 and 10.1, respectively, all P<0.05).Conclusion Comprehensive test of ADP, 25(OH)D3 and resistin is helpful to diagnosis of GDM and timely treatment.%目的：考察妊娠期糖尿病（ GDM）孕期动态血清脂联素（ ADP）、25-羟维生素D3[25（ OH） D3]和抵抗素的变化与临床意义。方法2013年1月至2014年1月在石家庄市第四医院产科门诊接受产前检查孕妇2000名，均于妊娠11～14周留取血样。所有孕妇均于24～28周行口服葡萄糖耐量试验（ OGTT）试验，其中86例孕妇诊断为GDM，选取其为研究对象，随机选取同期产检健康孕妇75例为对照。动态观察孕早、中、晚期血清中ADP、25（OH）D3和抵抗素水平。结果 GDM的发病率为4．3％（86/2000），随孕期进展，对照组和GDM组的中晚期ADP和25（OH）D3水平与早期相比均显著降低（ADP：F值分别为43．3、187．9；25（OH）D3：F值分别为8．7、9．3，均P＜0．05）；与对照组比较，GDM组孕早、中和晚期ADP和25（OH）D3水平均显著降低（ADP：t值分别为5．0、13．4、14．1；25（OH）D3：t值分别为2．5、2．1、2．2，均P＜0．05）。随孕期进展，两组的抵抗素水平中晚期与早期相比均显著增加（F值分别为149．3、56．0，均P＜0．05），与对照组比较，GDM组孕早、中和晚期抵抗素水平均显著增加（t值分别为15．8、15．4、10．1，均P＜0．05）。结论在妊娠早期综合检测ADP、25（OH）D3和抵抗素有利于综合诊断GDM，并给予及时治疗。
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