产科诊断超声对宫内绒毛细胞DNA的影响

摘要

目的：研究产科诊断超声的安全性。方法：用诊断超声照射早孕妇女子宫内的胚囊组织，照射时间长短不同，24小时后采取绒毛组织，测定绒毛细胞DNA单链断裂和双链断裂。结果：产科诊断超声照射10分钟以内，DNA单链断裂及双链断裂无增加，照射20分钟以上，DNA单链断裂和双链断裂增加。结论：诊断超声在产科应用于早孕时，应有明显的适应症，且使用最小剂量照射早孕胚囊。%Objective and Methods：In order to investigate the safety ofultrasonic diagnosis,clinical diagnostic ultrasound waves were exposed to embryos in uteri for varying exposed time.Chorionic villi were extracted after 24 hours of exposure and analyse of single and double strand DNA chain were done.Results:The embryos exposed to ultrasonic waves for more than 20 minutes had increased single and double strand broken.No marked change was observed in the embryos exposed for less than 10 minutes.Conclusions:This suggests that ultrasonic diagnosis during early embryonic period be limited to cases with good indications and the time of exposure be reduced as short as possible.