射频消融联合乙醇注射和生理盐水注射的离体猪肝实验研究

摘要

Objective To investigate whether radiofrequency ablation combined ethanol injection could widen necrosis in a single needle ablation. Methods Porcine liver in vitro were treated with RFA, QEA+ RFA, QEA+ RFA+NS using two types of RFA instruments, either RITA system or Cool-tip system. The volume of coagulated necrosis,total energy requirement and energy requirement for coagulation of per unit volume were analyzed. Results The volume of coagulated necrosis induced in the porcine liver was significantly larger in QEA+ RFA+ NS group than that in routine RFA group. In QEA+RFA group, the volume of coagulated necrosis was correlated with the type of RFA instrument. Compared to RFA alone, the amount of total energy requirement was higher and the energy requirement for coagulation of per unit volume are less in combined RFA. Conclusions Combined RFA enables to increase the volume of coagulated necrosis region significantly and reduce energy requirement for coagulation of per unit volume. It can induce comparable coagulated necrosis with smaller energy requirement.%目的 探讨多极无水乙醇注射(QEA)与射频消融(RFA)联合应用和消融过程中生理盐水(NS)注射能否提高单针消融范同.方法 应用离体猪肝分别采用RITA和Cool-tip系统进行RFA、QEA+RFA、QEA+RFA+NS,每组实验3次,比较各组消融灶的体积、能量及效能.结果 QEA+RFA+NS组的消融体积明显大于单独RFA组,而QEA+RFA组的消融体积则与消融方式有关.QEA+RFA组和QEA+RFA+NS组的效能均比单独RFA组要低,都能增加RFA的能量输出.结论 联合消融可以提高单针消融体积、减少效能.提高消融效率,对大小相同的肿瘤,应用较低功率就可以取得相同的消融凝固范围.