高血压性室间隔异常及其对左心室功能的影响

摘要

Twenty-one patients with hypertension were studied on their ventricular septal anatomy and dynamics.As a control,21 normal individuals without cardiovascular abnormality were studled simultaneously.The results showed that the mean thickness of ventrlLular septum was increased in hypertension group than in normal grouP(P<0.001).There was no significant difference in the left ventricular end-diastolic volume between the two groups(P>0.05),but very significant differences in the ventricular septal shortening index,left ventricular circumference shortening index,and left ventricular ejection fraction(P<0.001,<0.001,<0.01,respectively).In hypertension group.the ventricular septal shortening index had very good correlation with left ventricular circumference shortening index and left ventricular ejection fraction(r=0.803,0.894,n=21,P<0.001,respectively).It is concluded that echocardiographic examination of the ventricular septum can show the anatomic and dynamic abnormalites of the left ventricle. Transesophageal echocardiOgraphy offer reliable clinical information on the damage of the left ventricle caused by hypertension.%以经食道心脏超声技术检测21例原发高血压患者室间隔解剖和功能学改变,并以21例正常人作对照.结果为,高血压组室间隔平均厚度显著大于正常人组(P<0.001).高血压患者左心室舒张末期容量与正常人无显著差异(P>0.05),但其室间隔收缩指数、左心室周径缩短指数或左心室射血分数等均较正常人显著为低(P<0.001,<0.001,<0.01,依次).高血压患者室间隔收缩指数减低与其左心室周径缩短指数或左心室射血分数减低均有良好相关性(r=0.803,0.894,P<0.001,分别).结论为高血压性室间隔异常与左心室功能异常密切相关,经食道心脏超声可为临床提供高血压性左心室功能损害的可靠信息.