Objective To investigate the clinical usefulness of color Doppler ultrasonography(CDUS)-guided biopsy for pancreatic masses.Methods US-guided biopsy was performed in 181 patients who were hard diagnosed clinically to avoid vessels.The high suspected parts of tissue within mass was taken by using 21G biopsy needle in 166 cases and 18G needle in 15 cases. A biopsy was considered successful when the pathologist rendered a specific benign or malignant diagnosis.Results The sensitivity, specificity and diagnostic accuracy of the method were 97.0%,100%, and 97.7%, respectively. And for 18G and 21G needle were 100% and 96.8%, 100% both, 100% and 97.5%,respectively. There were complications (totally 1.7%) in two cases of acute pancreatitis and one case of subcutaneous seeding of pancreatic carcinoma.Conclusions It is of value to biopsy sensitivity, less complications, and knowing relationship between mass and blood vessels surrounded with CDUS-guided for percutaneous biopsy of pancreatic masses.For reducing the incidence of complications,it is important to take the indication of biopsy as a serious thing and puncture mass avoiding passing vessels and normal pancreatic tissue.%目的探讨彩超引导下胰腺占位病变穿刺活检的临床应用价值。方法 181例临床难以确诊的胰腺占位病变，彩超引导下避开大血管进针并对病灶内高度可疑处取材，细针取材166例，粗针取材15例，所取组织有明确病理诊断者为取材满意。结果 173例能作出明确组织病理学诊断者良恶性诊断的敏感性、特异性及准确性分别为 97.0%、100%、97.7%，其中18G组织切割针、21G Sonopsy-C1负压抽吸式切割针分别为100%、96.8%，100%、100%，100%、97.5%。本组并发症3例，占 1.7%，为2例急性胰腺炎及1例腹壁针道处肿瘤种植。结论彩超引导下胰腺活检能提高取材准确性、降低并发症及提供病变与周围血管关系的信息。严格掌握穿刺适应证及彩超引导避开大血管及正常胰腺组织进针是降低并发症的关键。
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