运动诱发气道痉挛与特应质的关系

摘要

Objective To investigate the correlation between exercise-induced bronchoconstriction and atopy.Methods Exercise-induced bronchoconstriction (EIB) was defined by free running asthma screening test.Atopy was defined by serum total IgE level and skin allergen test.Airway hyperreactivity was determined by bronchial provocation test.For a matched pair study,all EIB and some non-EIB students received serum total IgE measurements,skin allergen test and bronchial provocation test. All data were calculated by correlation analysis to investigate the correlation between EIB and atopy.Results Totally 773students participated in the free running screening test,and 89 students (11.5％) were diagnosed as having EIB.The serum total IgE level exceeded the normal range in 16 among the 89 EIB students,but in 10 among the 70 non- EIB students.Statistical analysis (x2 test) did not support the correlation between atopy and EIB.Fifty EIB students received bronchial provocation test,but only 1 showed airway hyperreactivity.Conclusion There was no correlation between atopy and EIB,and airway hyperreactivity was absent in most of the EIB students.%目的 调查运动诱发气道痉挛( EIB)和特应质之间的关系.方法 采取整群抽样的方法选取北京市城区和郊区各1所中学学生,利用运动筛查试验的方法调查EIB的发生率,通过血清总IgE水平和皮肤过敏原点刺结果判断特应质,根据支气管激发试验判断气道高反应性.将发生EIB的学生(EIB组)与正常学生(对照组)进行配对分析,均接受皮肤过敏原点刺、血清总IgE水平测定和支气管激发试验,利用相关分析方法判断EIB和特应质的关系,分析EIB学生气道高反应的发生情况.结果 共773名10～13岁学生(男389名,女384名)参加研究,其中89名学生(EIB组,男43名、女46名)运动筛查试验阳性,EIB发生率为11.5％ (89/773)；EIB组89名学生中,16人血清总IgE水平和皮肤过敏原点刺结果超过正常上限,对照组70名学生中,10人血清总IgE水平和皮肤过敏原点刺结果超过正常上限.通过x2检验发现,特应质与EIB之间无明显相关；50名接受支气管激发试验的EIB组学生中,只有1名呈阳性结果.结论 特应质与EIB发病无明显相关.绝大多数EIB学生不存在气道高反应.