听源性惊厥大鼠脑星形胶质细胞Xx43表达增加对神经元保护的机制

摘要

Objective To observe the alteration of the expression of Cx43 in cerebral astrocyte caused by audiogenic seizure.Method Genetic epilepsy prone rat P77PMC was used as a model and immunohistochemical method was applied to detect the time course alteration of Cx43 expression in P77PMC rat's cerebral astrocyte.Result After audiogenic seizure,Cx43 expression was detected in cerebral cortex and hippocampus and appeared time dependent increasing.Conclusion Astrocytes in cerebral cortex and hippocampus might be activated by audiogenic seizure,which might be beneficial to keep the stability of neuron's peripheral environment and thus protect the neurons.