壳聚糖/介孔生物活性玻璃多孔膜的制备和表征

摘要

BACKGROUND: Chitosan (CS) and mesoporo us bioactive glasses (MBG) have some good properties, such as bio com pati bil ity and hemostasis, but the hemostatic effect of CS is limited and it is inconvenient to use the MB<3 directly. OBJECTIVE: To prepare C S/MBG porous filmsMETHODS: CS and MBG porous film was prepared through a freeze drying process. The prepared porous films were characterized by us ing Fourier transform infrared spectres copy, scanning electron microscope and X-ray diffraction. In addtion, water adsorption, swelling ratio, the porosity and the mechanical property of the porous films were also studied. RESLUTS AND CONCLUSION: CS/MBG could be blended homogeneously via the lyophilization. The hole of the porous films was relatively uniform. The porous films showed good water adsorption character, which could be modulated by varying the weight ratio of CS and MBG. The prepared porous films had a higher porosity. The composite films can be potentially applied as a wound dressing material.%背景:壳聚糖和介孔生物玻璃都具有良好的生物相容性和止血性能,但壳聚糖止血作用有限,介孔生物玻璃粉体方式止血,给应用带来不便.目的:制备壳聚糖/介孔生物玻璃复合多孔膜并检测材料的性能.方法:采用冷冻干燥法制备壳聚糖/介孔生物玻璃复合多孔膜.结果与结论:通过冷冻干燥法可以实现壳聚糖和介孔生物玻璃的均匀复合.制备的复合多孔膜的孔隙分布较均匀;多孔膜具有很好的吸水性,吸水率的大小与壳聚糖和介孔生物玻璃质量比相关;多孔膜的孔隙率高.