医用透明质酸修复慢性牙周炎：可有效促进牙周组织再生

摘要

BACKGROUND:Hyaluronic acid has antioxidant, immune regulation, anti-inflammatory roles as wel as promotes wound healing. Hyaluronic acid is more and more applied in the treatment of chronic periodontitis and achieves a significant effect. OBJECTIVE: To observe the clinical effects of local application of sodium hyaluronate in the treatment of chronic periodontitis. METHODS:Sixty cases of chronic periodontitis (300 teeth) were selected. According to self-control method, the teeth in district A, 150 premolars or molars, were as experimental group, and other 150 teeth in district B served as control group. In the experimental group, periodontal scaling, subgingival scaling, and local application of Gengigel gel (0.2% hyaluronic acid) in the gingival sulcus were employed; in the control group, the treatment was same to that in the experimental group except local application of Gengigel gel. During 8-week folow-up, dental plaque index, sulcus bleeding index, probing depth, and clinical attachment loss were changed dynamicaly. RESULTS AND CONCLUSION:After treatment, al the measurement indexes were improved remarkably in the two groups. However, there was no difference in the dental plaque index between the two groups at 1, 4, 8 weeks after treatment. The sulcus bleeding index was lower in the experimental group than the control group at 1, 4, 8 weeks after treatment (P < 0.05). The periodontal probing depth of the experimental group was lower than that of the control group at 4 and 8 weeks (P < 0.05). The clinical attachment loss was lower in the experimental group than the control group at 8 weeks (P < 0.05). These findings indicate that periodontal treatment with local application of sodium hyaluronate in the gingival sulcus is significantly effective for the treatment of chronic periodontitis.%背景：据报道，透明质酸具有抗氧化、调节免疫、抗炎和促进伤口愈合等作用。在口腔治疗领域，越来越多的临床医师将透明质酸应用于慢性牙周炎治疗取得了显著疗效。目的：观察局部应用医用透明质酸钠治疗慢性牙周炎的临床效果。方法：选择60例慢性牙周炎患者共300颗患牙，采用口内自身对照的研究方法，受试者A区前磨牙、磨牙150颗为实验组，受试者B区前磨牙、磨牙150颗为对照组。实验组治疗方法为牙周洁治、龈下刮治治疗与龈沟内局部应用Gengigel凝胶(0.2%透明质酸)涂抹上药，对照组进行与实验组相同的全部牙周基础治疗，之后不进行龈沟内上药处理。随访8周，观察两组患牙菌斑指数、龈沟出血指数、牙周探诊深和附着丧失水平等临床指标的动态变化。结果与结论：两组临床治疗后各项检测指标较治疗之前都有明显改善。两组治疗1，4，8周的菌斑指数比较差异无显著性意义；实验组治疗后1，4，8周的龈沟出血指数低于对照组(P <0.05)；实验组治疗4，8周后的牙周探诊深度均低于对照组(P <0.05)；实验组治疗8周后的附着丧失低于对照组(P <0.05)。结果表明，牙周基础治疗配合龈沟内局部应用医用透明质酸钠治疗慢性牙周炎临床疗效显著。