背景：利用生物膜引导骨再生技术在上颌窦提升中成骨是牙种植的研究热点。目的：探讨引导骨再生技术在上颌窦提升中的成骨效果。方法：9只比格犬进行双侧上颌窦底提升同期牙种植，实验侧行胶原膜覆盖颊侧创口，对照侧无胶原膜覆盖。术后4，12，24周分别处死实验犬，行大体标本、力学测试及组织学检查。结果与结论：术后12，24周时对照侧骨移植材料有移位，骨质吸收明显，种植体顶部暴露，实验侧种植体顶部骨移植材料无移位现象，有较厚的骨质覆盖。随时间的增加，种植体牵出力增加，在24周时实验侧与对照侧差异有显著性意义(P <0.05)。组织学检查可见双侧上颌窦底植入骨粉后均可见新生骨形成，随时间延长逐渐增多、成熟，骨粉颗粒逐渐减少，术后12，24周时实验组与对照组新生骨的面积比较差异有显著性意义(P <0.05)。结果显示生物膜引导再生技术可减少上颌窦提升后骨的吸收，促进新骨骨形成。%BACKGROUND:The use of bio-membrane guided bone regeneration in maxilary sinus augmentation is a research hotspot in implantology at present. OBJECTIVE:To investigate the osteogenic effect of guided bone regeneration in maxilary sinus augmentation using colagen membranes. METHODS:The first maxilary molars of nine adult female beagle dogs were extracted and ful-thickness flap was reflected bilateraly, then the sinus floors were lifted with simultaneous implantation. Bio-Oss was placed into the new space under the sinus membrane. On the experimental side in each dog, the bio-membrane covered the osteotomy window. On the control side, the flap was sutured directly, and was not covered by bio-membrane. Two animals were sacrificed at 4, 12, and 24 weeks after surgery, respectively. Gross observation, biomechanical testing and histological examinations were performed. RESULTS AND CONCLUSION: In gross view, new bone formation was observed in al maxilary sinuses. The pul-out force increased with time. At week 24, a significant difference in the pul-out force was noted between the two groups (P < 0.05). Histomorphbomatrical analysis showed much more new caluses at the experimental group than the control group at weeks 12 and 24 after surgery (P < 0.05). The bio-membrane guided bone regeneration has a better effect on new bone formation in the sinus augmentation.
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