MG53蛋白对器官缺血再灌注损伤保护作用的现在与未来

摘要

背景:近年来随着休克治疗的进步以及动脉搭桥术、溶栓疗法、经皮腔内冠状动脉成形术、心脏外科体外循环、心肺脑复苏,断肢再植和器官移植等方法的建立和推广应用,多种器官缺血后重新得到血液再灌注.但缺血一定时间的器官重新恢复血液供应后,会出现损伤加重的表现.目的:总结MG53蛋白在5种器官缺血再灌注损伤保护中的研究和进展,并为其进一步研究提供有益的参考.方法:应用计算机检索1986至2016年PubMed、读秀学术搜索和CNKI数据库相关文章,英文检索词为"MG53,TRIM,Mitsugumin53,ischemic,reperfusion,Preconditioning,Preconditioning,RISK,membrane damage,Connexin43,KChIP2",中文检索词为"MG53蛋白,缺血再灌注".根据纳入与排除标准,最终保留61篇文献进行综述.结果与结论:①内源性MG53蛋白作为一种肌特异性膜修复蛋白,能参与肌细胞膜损伤修复作用和缺血预适应、缺血后适应保护作用;②外源性重组人MG53蛋白不仅对多种肌和非肌细胞膜损伤发挥修复作用,而且对心肌、骨骼肌、脑、肺脏和肾脏在内的多种器官缺血再灌注损伤还具有保护作用.%BACKGROUND: In recent years, with the progress of shock therapy as well as the establishment and promoted application of arterial bypass grafting, thrombolytic therapy, percutaneous transluminal coronary angioplasty, extracorporeal circulation on cardiac surgery, cardiopulmonary resuscitation, limb replantation, and organ transplantation, blood reperfusion in multiple organs after ischemia has been achieved. However, the organs which undergo a period of ischemia appear to have the performance of damage aggravation.OBJECTIVE: To summarize the research progress of MG53 protein in protecting five organs from ischemia/reperfusion injury, thereby providing reference for further in-depth study.METHODS: A computer-based online search of PubMed, Duxiu Knowledge Search and CNKI databases was performed for relevant literatures puldished between 1986 and 2016. The key words were "MG53, TRIM, Mitsugumin53, ischemic, reperfusion, preconditioning, postconditioning, RISK, membrane damage, Connexin43, KChIP2" in English and "MG53, ischemia/reperfusion" in Chinese. Finally 61 eligible articles were reviewed in accordance with the inclusion and exclusion criteria. RESULTS AND CONCLUSION: As a muscle-specific TRIM family protein, endogenous MG53 is involved in the repair of muscle cytomembrane damage, and the protective effects of ischemic preconditioning and postconditioning. Exogenous recombinant human MG 53 protein not only repairs membrane damage of various muscles and non-muscle cells, but also protects the myocardium, skeletal muscle, brain, lung and kidney from ischemia/reperfusion injury.