高危Fontan患儿术前经皮介入封堵肺动脉前向血流的疗效

摘要

目的 探讨高危Fontan手术患儿术前经皮介入封堵肺动脉前向血流的治疗效果.方法 回顾性分析2016年5月至2018年8月在上海交通大学医学院附属上海儿童医学中心心胸外科接受外科治疗的6例Fontan手术患儿,男4例,女2例;年龄(5.7±2.9)岁;体质量(19.8±5.5)kg.6例均行一期肺动脉环缩术(PAB),二期行双向Glenn术(BDG)并re-PAB.Fontan术前于心内科行心导管造影术同时封堵肺动脉前向血流.结果 6例于心内科行介入治疗,封堵前肺动脉平均压力(17.0±0.8)mmHg(1 mmHg=0.133 kPa),心室舒张末压力(VEDP)(11.2±0.9)mmHg,封堵后肺动脉平均压力均有效下降至(14.2±0.7)mmHg,VEDP下降至(9.7±0.7)mmHg.封堵术后6～12月,实施Fontan手术,术后无死亡,患儿各项临床指标正常.随访2～24个月,患儿心功能及各脏器功能恢复良好.结论 对部分高危Fontan术前患儿,利用心导管介入封堵肺动脉前向血流能够安全、有效地降低平均肺动脉压力、减轻心室及肺血管负荷,对成功实施Fontan手术有极大帮助.%Objective To investigate the therapeutic effect of the transcatheter closure of antegrade pulmonary blood flow with high-risk Fontan operations.Methods Retrospective analysis of 6 Fontan surgical patients, 4 males and 2 females, who received surgical treatment in the cardiothoracic surgery of Shanghai Children's Medical Center from May 2016 to August 2018;Age(5.7 ±2.9) years;(19.8 ±5.5) kg weight.All 6 patients were treated with primary pulmonary artery banding operation and secondary bilateral Glenn operation(BDG) and re-PAB.Before Fontan surgery, cardiac catheterization was performed in the department of cardiology to close the antegrade pulmonary blood flow .Results These six patients received interventional therapy in the department of cardiology.The mean pulmonary artery pressure(Pp) before occlusion was(17.0 ±0.8) mmHg (1 mmHg=0.133 kPa), the ventricular diastolic pressure(VEDP) was (11.2 ±0.9) mmHg, and the mean pulmonary artery pressure after occlusion was effectively decreased to(14.2 ±0.7) mmHg and VEDP to(9.7 ±0.7) mmHg.Fontan surgery was performed 6 to 12 months after the occlusion.No death was found after the operation, and all the clinical indicators were normal after the operation.Follow-up was conducted for 2-24 months, and the cardiac function and the function of each organ recov-ered well.Conclusion For some patients with high risk Fontan before operation , this method can safely and effectively reduce the average pulmonary artery pressure and reduce the ventricular and pulmonary vascular load , which is of positive help for the successful Fontan operation.