心房颤动患者左心房纤维化对射频消融术后心律的影响

摘要

Objective To research the fibrosis characteristics of Atrial Fibrillation(AF) patients under microscope and its effect to post-operative sinus conversion of Radiofrequency ablation treatment.Methods Based on Lefi Atrial Dimension (LAD).Left atrial appendage tissue samples of 60 AF patients who received bipolar radiofrequency ablation treatment during open heart surgery between July and December 2011,were divided into 4 groups:group a (LAD≤50 mm),group b (50 mm ＜ LAD≤60 mm),group c (60 mm＜ LAD ≤70 mm),group d (LAD ＞ 70 mm),15 patients in each group.The levels of atrial muscle fibrosis and cell size differences are compared for colored slides of samples.Research are done for the difference of sinus rhythm restoration rate among the 4 groups based on ECG records at immediate,leaving hospital,and 3,6,12 months postoperative are collected for all groups.Results Differences of CVF and atrial muscle cell size measured under microscope are statistically meaningful(P ＜ 0.001).Sinus rhythm restoration rate differences at 6 month(P =0.039) and 12 month (P =0.037) post-operative are statistically meaningful.Further,immediate,leaving hospital,and 3,6,12 months postoperative sinus rhythm restoration rates are 93.3％,93.3％,93.3％,100％,100％ for group a,80.0％,73.3％,80.0％,80.0％,80.0％ for group b,66.7％,66.7％,66.7％,73.3％,66.7％ for goup c,and 53.3％,53.3％,53.3％,60.0％,60.0％ for group d respectively.Conclusion For rheumatic heart valve diseases patients who at 6 and 12 month post-operative,the greater the LAD,the higher the atrial fibrosis level,the greater the cell size,the lower the sinus rhythm restoration rate is.%目的 探讨心房颤动患者左心房纤维化特点及其对外科射频消融术后窦性心律恢复的影响.方法 选取2011年7月至9月北京安贞医院心外科九病房心脏直视手术同期行双极射频消融术患者60例,均为风湿性心脏瓣膜病持续性及永久性房颤,术中射频消融前取左心耳病理标本.根据术前左心房内径(LAD)不同,分为a组(LAD≤50 mm)、b组(50 mm＜ LAD≤60 mm)、c组(60 mm＜LAD≤70 mm)、d组(LAD ＞70 mm),每组各15例.标本切片染色后,比较4组心房肌纤维化程度及细胞径差异.收集患者术后即刻、出院时心电图,随访术后第3、6、12个月心电图,研究4组患者术后窦性心律恢复情况.结果 4组显微镜下测得胶原容积分数值和心肌细胞径差异均有统计学意义(P＜0.001)；术后6、12个月窦性心律恢复率差异有统计学意义(P＜0.05).患者术后即刻、出院时、3、6、12个月窦性心律恢复率分别为,a组93.3％、93.3％、93.3％、100％、100％；b组80.0％、73.3％、80.0％、80.0％、80.0％;c组66.7％、66.7％、66.7％、73.3％、66.7％;d组53.3％、53.3％、53.3％、60.0％、60.0％.结论 风湿性心脏病房颤患者术前左心房内径越大、心房纤维化程度越高,心肌细胞径越大外科射频消融术后6及12个月窦性心律维持率越低.