脉管癌栓对食管鳞状细胞癌预后的影响

摘要

Objective To investigate the prognostic significance of the angiolymphatic invasion(ALI) in patients with esophageal squamous cancer(ESCC) who received radical resection.Methods A retrospective review was performed on 355 patients who underwent radical resection for ESCC in our hospital between June 2005 and December 2008.Clinicopathological features and overall survival rate were surveyed.Results Of all the patients included, these 46 ESCC patients with angiolymphatic(ALI group) invasion accounted for 13.3％.The 5-year overall survival rate was 20.3％ in patients of ALI group and 40.2％ in those of non-ALI group(P =0.001).The histological differentiation was poorer in the ALI group (P =0.008) as compared with non-ALI group.Univariate analysis showed that body mass index(BMI), ALI, T stage, N stage, and differentiation were associated with survival(P ＜ 0.05 for all).Multivariate analysis revealed that ALI, N stage, T stage and BMI were independent risk factors of prognosis.Conclusion This study highlights that ALI may facilitate the stratification of patients with a poor prognosis after radical resection for ESCC.%目的 探讨食管鳞癌合并脉管癌栓患者的临床病理特点、生存率以及影响食管鳞癌患者预后的因素.方法 回顾2005年6月至2008年12月手术治疗食管鳞癌患者的资料,分析其临床病理特点及脉管癌栓对术后生存的影响.结果 共收集355例患者,其中脉管癌栓阳性患者46例(13.3％).脉管癌栓阳性和阴性患者的5年生存率分别为20.3％和40.2％.单因素分析结果显示,影响总生存率的因素为T分期、N分期,体质指数、组织分化和脉管癌栓.多因素分析结果显示T分期、N分期、体质指数及脉管癌栓是影响预后的独立因素.结论 食管鳞癌合并脉管癌栓患者具有较差的生物学特性,且脉管癌栓是影响食管鳞癌预后的独立因素.