7-硝基-8-羟基喹啉的合成

摘要

7-Nitro-8-quinolinol in overall yield of 69% with more than 99% purity was synthesized from 8-quinolinol by a two-step reaction of nitration and desulfonation. The structure was confirmed by 1H NMR, 13C NMR and HR-MS.%以8-羟基喹啉为原料,经硝化和脱磺酸基保护两步反应合成了7-硝基-8-羟基喹啉,总收率69％,纯度高于99％.其结构经1H NMR,13C NMR和HR-MS确证.