1-对硝基苯基-3-甲基-4-(α-噻吩甲酰基)-5-吡唑啉酮的合成

摘要

对硝基苯肼与乙酰乙酸乙酯经亲核闭环制得1-对硝基苯基-3-甲基-5-吡唑啉酮(1)；1与α-噻吩甲酰氯进行克莱森缩合合成了新化合物——1-对硝基苯基-3-甲基-4-(α-噻吩甲酰基)-5-吡唑啉酮,其结构经1H NMR,13C NMR,IR,MS和元素分析表征.%A new compound,3-methyl-1-(p-nitrophenylhydrazine)-4-(α-thenoyl)-5-pyrazol-one,was synthesized by Claisen condensation reaction from α-thenoyl chloride and 3-methyl-1-(p-nitrophe-nylhydrazine)-5-pyrazolone,which was prepared by nucleophilic ring-closing reaction of p-nitrophe-nylhydrazine and ethyl acetoacetate.The structure was characterized by 1H NMR,13C NMR,IR,MS and elemental analysis.