18 F标记前体3′-甲氧基-7-对甲苯磺酰r氧丙氧基槲皮素的合成

摘要

以槲皮素为起始原料,经酰化、醚化、苄醚化、脱苄、甲基化、水解6步反应合成了18 F标记前体3′-甲氧基-7-对甲苯磺酰氧丙氧基槲皮素,其结构经1 H NMR,13 C NMR和HR-MS(ESI)确证.%The 18 F labeled precursor of 3-{[3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl] oxy}-propyl-4-methylbenzenesulfonate was synthesized by a six-step reaction of acyla-tion, esterification, etherification, debenzylation, methylation and hydrolyzation. The structure was confirmed by 1 H NMR, 13 C NMR and HR-MS( ESI) .