N，N-二甲基乙酰胺促进N-取代肉桂酰胺的合成

摘要

Ten N-substituted cinnamamides ( 3 a ~3 j ) were synthesized by chlorination of cinnamic acid with thionyl chloride in DMAc (4 mL) at 0 ℃for 20 min, followed by amidation with arylamines at 25 ℃for 3 h.The yield of 3a~3j were 85.8%~96.5%.The structures were confirmed by 1 H NMR, 13 C NMR, IR and EI-MS.The proposed mechanism for the promotion of DMAc for the reaction was suggested .%以肉桂酸为原料，N，N-二甲基乙酰胺（ DMAc，4 mL）为促进剂，先与SOCl2于0℃反应20 min，再与芳胺于25℃反应3 h，合成了10个N-取代肉桂酰胺（3a～3j），产率85．8％～96．5％，其结构经1H NMR，13C NMR， IR和EI-MS确证。提出了DMAc促进反应的可能机理。