术前限制性与开放性液体治疗对胰腺手术围手术期安全性影响的Meta分析

摘要

目的 探讨术前限制性液体治疗与开放性液体治疗对胰腺手术围手术期安全性的影响.方法 计算机检索英文数据库PubMed、Embase和Cochrane Library,收集有关比较胰腺手术限制性与开放性液体治疗疗效的随机对照试验研究.由2名研究者按照纳入和排除标准独立筛选文献,并对纳入的文献进行资料提取和质量评价.采用RevMan 5.3软件进行统计学分析.结果 最终纳入4篇研究,共785例患者,其中限制性组396例,开放性组389例.Meta分析结果显示,限制性组与开放性组患者的术中出血量、术后并发症发生率、病死率、住院期间再手术率及住院时间等差异均无统计学意义(P值均≥0.05).结论 对于胰腺手术,限制性液体治疗并无明显优势.%Objective To assess the perioperative safety of preoperative restricted fluid administration and liberal fluid administration for pancreatic surgery.Methods The randomized controlled trials comparing restricted and liberal in pancreatic surgery were collected by searching the databases of PubMed,Embase and the Cochrane Library.Two reviewers independently selected studies according to the inclusion and exclusion criteria,then extracted the data and assessed the quality of included studies.Metaanalysis was performed by RevMan 5.3 software.Results A total of 4 studies involving 785 patients were finally included,with 396 cases in restricted group and 389 cases in liberal group.Results of Meta-analysis showed that there was no statistically significant difference between the two groups in terms of intraoperative blood loss,postoperative complications,mortality,reoperation in-hospital and length of stay (all P≥ 0.05).Conclusion With regard to pancreatic surgery,restricted fluid administration do not have outstanding advantages.