Synthesis and Crystal Structure of 3-(2-Hydroxybenzly)-4-(4-Hydroxybenzylideneamino)-(1H)-1,2,4-Triazole-5-Thione and Its Antibacterial Activities

摘要

The title compound C15H12N4O2S was synthesized by the reaction of 3-(2-hydroxy- benzyl)-4-amino-(1H)-1,2,4-triazole-5-thione with 4-hydroxybenzaldehyde in ethanol and charac- terized by IR, 1H NMR spectra and elemental analysis. Its structure has been determined by X-ray diffraction analysis. The crystal belongs to monoclinic, space group C2/c with a = 27.990(3), b = 13.1326(14), c = 7.9770(8)(A), β = 105.787(2)o, V = 2821.6(5) (A)3, Z = 8, Mr = 312.35, μ = 0.243 mm-1, Dc = 1.471 g/cm3 and F(000) = 1296. The structure was solved by direct methods and refined to a Rint value of 0.0388. The crystal structure involving in intermolecular N-H…S and O-H…S hydrogen bonds is observed, meanwhile intramolecular O-H…N hydrogen bond is also found. Their biological activities have been measured. The results show that this type of compound has certain antibacterial activity for Staphylococous aureus and Bacillus subtilis.