蛛网膜下腔出血早期脑损伤发病机制综述

摘要

Spontaneous subarachnoid hemorrhage is a common cerebrovascular disease, with high mortality and disability. Although drugs and surgery technology progress gradually, there is no obvious improvement on functional outcomes in survivors. Traditional views consider vasospasm is the main cause of death and disability of subarachnoid hemorrhage, and a great progress has been made in the treatment of vasospasm in recent years, but the prognosis of patients is still bad. At present, many foreign studies have found that early brain injury may be a main factor of poor prognosis of subarachnoid hemorrhage.%自发性蛛网膜下腔出血是常见的脑血管疾病，死亡率及致残率高。尽管药物及外科手术技术逐渐进步，但是并没有明显改善存活患者的功能预后。传统的观点认为血管痉挛是蛛网膜下腔出血死亡及致残的主要原因，近年来针对血管痉挛的治疗也有了巨大的进步，但是患者的预后仍然很差。目前国外许多研究发现，早期脑损伤可能是蛛网膜下腔出血预后不良的主要因素。