经颅彩色多普勒超声对帕金森病的诊断价值

摘要

Parkinson's disease is a progressive neurological disorder, which results from the degeneration of dopamine-producing cells in the substantia nigra (SN). Clinical symptoms typically include static tremor, bradykinesia, myotonia, and postural instability. However, clinical features in the early stages of Parkinson's disease are atypical. Therefore, it is important to develop a diagnostic tool aimed to recognize the early stages of Parkinson's disease. Transcranial color-coded sonography as a non-invasive technology has become an important instrument in the diagnosis of Parkinson's disease and in the differential diagnosis of Parkinsonism. Above all, transcranial color-coded sonography has the capability of detecting substantia nigra hyperechogenicity and shows stenosis of vessels, which plays an important role in diagonosing Parkinson's disease in its early stages and differentiating Parkinson's disease and vascular parkinsonism. The main purpose of the current article is to summarize the significance of transcranial color-coded sonography in the diagnosis and differential diagnosis of Parkinson's disease.%帕金森病是一种由于黑质的多巴胺细胞变性导致的一种神经系统退行性疾病。临床典型症状包括静止性震颤、运动迟缓、肌强直和姿势障碍。然而，帕金森病的早期阶段症状并不典型。因此发展一种早期诊断帕金森病的手段是非常必要的。经颅彩色多普勒超声作为一种非侵入性的技术，已成为帕金森病的诊断及与帕金森综合征鉴别诊断的重要工具。最重要的是，经颅彩色多普勒超声不仅能够探测黑质的高回声，同时能够检测到血管的狭窄程度，是早期诊断帕金森病及能够鉴别诊断血管性帕金森综合征的关键。