伏格特-小柳-原田综合征脑实质损害症状的临床分析

摘要

目的 总结伏格特-小柳-原田综合征的神经系统症状损害特点.方法 回顾性分析住院伏格特-小柳-原田综合征患者的临床资料,对患者的临床表现、神经系统症状、实验室及磁共振成像(magnetic resonance imaging,MRI)检查结果、治疗等进行描述性分析.结果 研究共纳入36例患者,其中30例(83.33%)患者出现神经系统症状,以头痛最为常见(29例,80.56%),卒中样表现包括肢体及面部麻木(1例,2.78%)、步态不稳(1例,2.78%)、意识障碍(1例,2.78%)等.有卒中样症状的患者MRI可见脱髓鞘表现,但未见新发梗死灶.结论 伏格特-小柳-原田综合征中可出现脑实质损害症状,在MRI上可表现为脱髓鞘改变.%Objective To summarize the clinical characteristics of the nervous system symptoms in patients with Vogt-Koyanagi-Harada syndrome. Methods Clinical materials of the inpatients with Vogt-Koyanagi-Harada syndrome were retrospectively analyzed. The clinical features, nervous system symptoms, results of lab tests and magnetic resonance imaging (MRI), treatment and prognosis were descriptively analyzed. Results Thirty-six cases were collected, of which 30 (83.33%) cases presented with nervous system symptoms, and headache was the most common (29 cases, 80.56%). Stroke-like symptoms included limbs and facial numbness (1 case, 2.78%), walking unstable (1 case, 2.78%), conscious disturbance (1 case, 2.78%). Demyelination sign can be seen on the MRI of the patients with stroke-like symptoms, yet without new infarction lesion. Conclusion Symptoms associated with cerebral parenchyma injury are uncommon in patients with Vogt-Koyanagi-Harada syndrome, presenting demyelination sign on MRI.