Objective To explore the factors related with neurological function in children after hemispherectomy for intractable epilep-sy. Methods Thirty-three children suffered hemispherectomy from May, 2014 to June, 2015 were analyzed. Their preoperative data were col-lected. A structured questionnaire was used to evaluate the neurological function. The relationship between preoperative parameters and post-operative functional outcomes was analyzed. Results Bilateral lesions in MRI (P<0.001) and age (P<0.001) were related with functional out-come. Conclusion The prognosis of hemispherectomy for children with intractable epilepsy is related to the contralateral lesion and age.%目的：探讨大脑半球离断术患儿术前各项临床指标对术后各项神经功能的影响。方法回顾性分析本中心自2014年5月~2015年6月实施大脑半球离断术的患儿33例。收集手术前临床资料。通过门诊及电话随访，以结构化问卷评估术前、术后神经功能状态。采用Fisher精确概率法对术前临床资料与术后功能进行单因素分析。结果 MRI为双侧病变对患儿术后肢体活动能力的预后有重要影响(P<0.001)。患儿年龄影响术后肢体活动能力的预后(以3岁为界定)(P<0.001)，年龄小的患儿术后功能恢复较好，年龄对口语能力(以3岁为界)及阅读能力(以10岁为界)也有一定影响(P<0.001)。结论难治性癫痫大脑半球离断术术后神经功能预后与患儿对侧半球病变及患儿年龄有关。
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