游泳运动对2型糖尿病大鼠炎症和氧化应激状态的影响

摘要

目的:探讨游泳运动对2型糖尿病大鼠血清炎症和氧化应激状态的影响.方法:采用高脂饲料喂养加注射链脲佐菌素的方法建立糖尿病大鼠模型,随机分为糖尿病对照组,糖尿病急性力竭游泳组,糖尿病游泳训练组,同时设立正常对照组,游泳训练8周和急性力竭游泳后取血观察大鼠血清葡萄糖、胰岛素、脂质代谢情况,以及炎症状态,氧化应激状态.结果:与糖尿病对照组比较,急性力竭游泳组大鼠显著降低了血糖和胰岛素,同时伴随炎症和氧化应激状态显著恶化.游泳训练组大鼠血糖和脂质代谢障碍改善,同时炎症和氧化应激状态显著降低.结论:由于抗炎和抗氧化的特性,慢性游泳运动训练对2型糖尿病大鼠代谢产生了有益的影响.%Objective:To investigate the effects of swimming exercise on inflammation and oxidative stress status in obese diabetic mellitus type2 rats.Method:Male Sprague Dawley rats diabetes mellitus type2 models were induced by feeding high fat diet after injection with streptozotocin(STZ),then they were divided into three groups randomly(diabetic control group,diabetic acute exhaustive swimming group,diabetic swimming training group),except those in normal control group.Rats were sacrificed after 8 weeks' of a swimming training program and after a single bout of acute exhaustive swimming.The serum glucose,insulin,total cholesterol(TC) and triglycerides(TGs),tumour necrosis factor-α (TNF-α),C-reactive protein(CRP),adiponectin,malondialdehyde(MDA),superoxide-dismutase(SOD) were detected.Result:When compared to diabetic control group,the rats submitted to acute swimming presented significantly lower values of glycaemia and insulinemia,with inflammatory profile and oxidative stress significantly aggravated.The training rats showed amelioration of glycaemia and lipidic dysmetabolism,accompanied by remarkable reduction of inflammatory and oxidative markers.Conclusion:Chronic swimming training produced beneficial effects on metabolism of diabetes mellitus type2 rats,due to anti-inflammatory and anti-oxidant properties.