抑郁患者对情绪刺激的注意偏向及其大脑功能磁共振成像证据

摘要

目的 探讨抑郁患者的注意偏向及其大脑功能磁共振成像证据.方法 采用17项汉密尔顿抑郁评定量表( HRSD17)并结合中国精神障碍分类与诊断标准筛选被试,分为患者组(9例,HRSD17评分≥17分)、康复组(9例,7分≤HRSD17评分＜17分)和对照组(10名,HRSD17评分＜7分),采用情绪斯特鲁普范式和功能磁共振成像技术,考察抑郁症患者对情绪面孔刺激的注意偏向及其大脑功能磁共振成像证据.结果 (1)康复组在消极、积极及中性条件下对情绪面孔刺激的颜色命名反应时[(701.85± 180.70)、( 635.58±119.79)、(598.88±130.41)ms]短于患者组[(991.04±194.23)、(888.22±184.16)、(745.59±165.38) ms],2组比较差异有统计学意义(P＜0.05),但与对照组[(649.40±143.35)、(633.28±120.50)、(565.69 ±89.87)ms]的差异无统计学意义(P＞0.05)；(2)在消极情绪面孔刺激下,康复组比患者组被激活更多的脑区,包括左右额上回和中回、右颞叶、左舌回和左枕叶等.结论 抑郁患者对负性刺激的注意偏向及其脑功能可能随临床康复进程获得改善.%Objective To explore the attentional biases in depressive patients and the evdence from functional magnetic resonace imaging (fMRI). Methods The Hamilton Rating Scales for Depression (HRSD17) and Chinese Classification of Mental Disorders (CCMD-3) were used to select the participants:the subjects were diagnosed into three categories according to the HRSD17 and CCMD-3:depression group (n =9,HRSD17 score ≥ 17 ),recovery group ( n =9,7 ≤ HRSD17 ＜ 17 ) and control group ( n =10,HRSD17 ＜ 7).The Emotional Stroop Task and fMRI were used to test the attentional bias and brain function of depressive patients under the stimulation of emotional face.Results ( 1 ) The recovery group' s reaction time (RT) under the stimulations of negative,positive and neutral emotional face [ (701.85 ± 180.70),(635.58 ± 119.79),(598.88 ± 130.41 ) ms] were significantly shorter than the depression group [(991.04±194.23),(888.22 ± 184.16),(745.59 ± 165.38) ms,P ＜0.05]; but there is no significant difference compared with the control group [ ( 649.40 ± 143.35 ),( 633.28 ± 120.50 ),(565.69 ± 89.87) ms,P ＞ 0.05 ].(2) The activation of brain lobes ( including the superior and middle gyrus of left and right frontal lobe,right temporal lobe,left lingual gyrus and left occipital lobe) under the stimulations of negative emotional face were significantly stronger and larger in recovery group than the depression group.Conclusion The findings suggest that the attention bias in negative information for the depressive patients may get weaker and their brain function may be improved in the precess of clinical recovery.