下颌骨滤泡树突细胞肉瘤1例报道并文献复习

摘要

Objective: To study the diagnosis and the treatment of the FDCS arising from the mandible bone. Methods: By inquiring and physical examination, X-Ray, CT scanning, immunohistochemical findings, one case arise from the mandible bone is reported with its related literature reviewed. Its diagnosis and treatment methods were analyzed. Results: The treatment program of this case is offered and used in therapy. Extensive osteotomy of mandible bone beyond 1.5cm of the tumor. After the operation, radiotherapy dose was suggested for 50Gy. The patient is still alive and has no locative recurrence for 5 years post-operation. Conclusions: FDCS is a rare hematologic tumor derived from follicular dendritic cell. The diagnosis of the FDCS in mandible bone is definited. Immunohistochemical feature enhances its sensitivity of the tumor which demonstrated CD21(+), CD35(+). Surgery appears to be clear for operable tumors and adjurant chemotherapy or radiotherapy should be considered for this tumor.%目的:探讨下颌骨滤泡树突细胞肉瘤(FDCS)的诊断与治疗.方法:报道1例发生于下颌骨的FDCS患者,通过问诊及专科查体,结合放射线、CT检查及病理检查,分析该病例的诊断和治疗,并对相关文献进行回顾.结果:手术采取在肿瘤外1.5cm截骨,并配合放疗,该患者经5年复诊未见复发.结论:初步明确下颌骨FDCS的诊断方法,确诊必须依靠免疫组化,主要特征为CD21(+),CD35(+),治疗应采取手术为主的综合治疗.