鼻内皮质类固醇膏剂治疗变应性鼻结膜炎的效果观察

摘要

Objective To investigate the therapeutic effect of short - term application of intranasal corticosteroid ointment in the treatment of allergic rhinoconjunctivitis ( ARC).Methods From December 2016 to December 2017,one hundred and sixty-four patients with ARC were diagnosed in the ophthalmological clinic of the Second Affiliated Hospital of Zhengzhou University,and they were divided into observation group (83 cases) and control group(81 cases) according to the digital table.The observation group was treated with tobramycin dexamethasone ophthalmic ointment,and the control group was treated with azzolastine hydrochloride eye drops.The scores of ocular, nasal symptoms and signs were recorded and compared with before treatment,and the clinical effective rates of the two groups were compared.Results After 14 days of treatment,the scores of nasal symptoms and signs in the two groups were significantly lower than those before treatment ( all P <0.05 ). In the observation group, the scores of nasal symptoms and signs after 14 days of treatment were lower than those in the control group,and the differences were statistically significant (t=3.048,P=0.008;t=3.098,P=0.028).The total effective rates of the observation group and control group were 79.51% and 48.19% ,respectively,the difference was statistically significant ( χ2 =18.644, P<0.05).Conclusion The short-term application of intranasal corticosteroid ointment can effectively relieve the clinical symptoms of ARC.The therapeutics is simple and effective,and it is safe and economical.It is very suitable for wide application and popularization in primary clinical hospitals.%目的 探讨鼻腔内短期应用皮质类固醇激素膏剂治疗变应性鼻结膜炎( ARC)的临床效果.方法 选择2016年12月至2017年12月在郑州大学第二附属医院眼科门诊治疗的ARC患者164例,采用随机数字表法分为观察组(83例)和对照组(81例).观察组妥布霉素地塞米松眼膏鼻内应用联合盐酸氮卓斯汀滴眼液点眼;对照组应用盐酸氮卓斯汀滴眼液点眼.记录两组患者治疗14 d后的眼部和鼻部症状和体征计分,与治疗前进行比较;比较两组患者治疗14 d后的临床有效率.结果 两组治疗14 d后患者眼、鼻部症状和体征计分均较治疗前明显降低(均P<0.05),观察组治疗14 d后眼、鼻部症状和体征计分低于对照组,两组差异均有统计学意义(t=3.048,P=0.008;t=3.098,P=0.028).观察组和对照组治疗总有效率分别为79.51%和48.19% ,两组差异有统计学意义(χ2 =18.644,P<0.05).结论 短期应用鼻内皮质类固醇类膏可有效缓解ARC临床症状,方法简便易行,效果显著,且安全经济.