Objective To explore the incidence rate of epilepsy secondary to Alzheimer ,s disease (AD)、its pathogenesis、clinical treatment and its effect on AD. Methods the data of 120 patients with AD from 2000-2012 were retrospectively ana-lyzed ,the incidence rate of Epilepsy secondary to AD was analyzed. 19 AD patients complicated with Epilepsy were classified to the observation group ,101 AD patients without Epilepsy to the control group. And then the clinical treatment and accessory examinations of 19 AD patients complicated with Epilepsy and the effect of Epilepsy on AD were analyzed. Results Among the 120 AD patients ,19 cases were complicated with Epilepsy (15.8% ) ,Among which ,7 cases occurred in early stage ,3 cases in middle ,9 cases in late ;according to the seizure types of Epilepsy ,they included :8 cases of generalized tonic-clonic seizure ,13 cases of complex partial seizures ,2 cases of simple partial seizure. 2 cases of the 19 patients had status epilepticus ;Mean age of AD patients with Epilepsy was less than that of AD without Epilepsy (P<0.05) ,mean survival time of AD patients with Epi-lepsy was shorter than that of those without Epilepsy (P<0.05) ;Brain atrophy was significantly obvious in AD with Epilepsy group ;The antiepileptic drug was not very effective in controlling the Epileptic seizure in patients with AD ,The frequency of Epileptic seizures increased as the symptoms of AD exacerbated. Conclusion The incidence rate of Epilepsy in AD is 15.8%.Epilepsy may occur at any time in AD ,mean age of onset of Epilepsy in AD is small ,mean survival time is short. Epilepsy can worsen AD symptoms and shorten the survival time of AD. The pathogenesis of Epilepsy in AD is associated with loss of neu-rons ,temporal lobe and hippocampal sclerosis. The antiepileptic drug is not very effective in controlling the Epileptic seizure in patients w ith AD.%目的：探讨阿尔茨海默病（AD ）伴发癫痫的发生率、机制、临床治疗及癫痫对AD病情的影响。方法回顾分析2000-2012年120例AD患者，分析癫痫发生率，将19例AD伴发癫痫病人设为观察组，101例AD不伴癫痫病人设为对照组，分析19例AD患者伴发癫痫的临床治疗、辅助检查结果及癫痫对 AD病情的影响。结果120例 AD 患者中19例（15.8％）伴癫痫发作，其中AD早期7例，中期3例，晚期9例；癫痫发作类型，全身性强直-阵挛发作8例，复杂部分性发作13例，单纯部分性发作2例，2例出现癫痫持续状态；AD伴癫痫组患者发病年龄明显小于AD不伴癫痫组（ P＜0.05），AD伴发癫痫组患者平均生存期明显短于AD不伴癫痫组（P＜0.05）；AD伴发癫痫组脑萎缩明显；AD病人出现癫痫，应用抗癫痫药物治疗效果欠佳，在AD症状加重时癫痫发作增多。结论 AD有15.8％伴癫痫发作，癫痫发作可在AD任何时期，AD伴发癫痫患者发病年龄小，癫痫加重AD病情发展，生存时间短。AD伴发癫痫相关的机制与神经元丧失、颞叶海马硬化有关，抗癫痫药物治疗效果欠佳。
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