血浆N端脑钠肽前体浓度变化与脑出血患者预后的相关分析

摘要

目的：探讨血浆N端脑钠肽前体浓度变化与脑出血患者预后的关系。方法选择我院2011-02-2013-02收治的52例脑出血患者的临床资料，并选择本院同期38例健康的体检人员作为对照组，探讨血浆N端脑钠肽前体浓度变化与脑出血患者预后的关系。结果脑出血患者组的NT-proBNP水平均明显高于对照组，且组间差异具有统计学意义（P＜0.05），且大量出血组患者的血浆 NT-proBNP水平明显高于中量和少量出血组，死亡患者的血浆 NT-proBNP水平达（1688.32±234.98）pg/mL ，明显高于好转组，且组间差异具有统计学意义（P＜0.05）；而在好转的45例患者中，NIHSS评分＞6分的患者其血浆NT-proBNP水平达（677.09±102.34）pg/mL ，明显高于 NIHSS评分≤6分的患者，且差异具有统计学意义（P＜0.05）。结论脑出血患者的血浆NT-proBNP水平明显增高对判断脑出血患者的预后恢复具有十分重要的意义，可作为临床脑出血诊断和治疗的重要参考指标。%Objective To investigate the relationship between plasma NT-proBNP concentration and prognosis of patients with cerebral hemorrhage.Methods Fifty-two patients with cerebral hemorrhage were taken as subjects ,and in the corre-sponding period ,38 cases for healthy medical examination were selected as control group.Results In the group of patients with cerebral hemorrhage ,NT-proBNP levels were significantly higher ,and the difference between the two groups was statistically significant(P<0.05) ,but also plasma NT-proBNP levels of patients with a lot of bleeding were significantly higher than those of patients with moderate and mild amount of bleeding ,plasma NT-proBNP levels of patients who died were up to (1688.32 ± 234.98)pg/mL ,significantly higher than those of the improvement group ,the difference between the groups was statistically significant (P<0.05);while in those 45 patients who improved ,plasma NT-proBNP levels of those whose NIHSS score>6 points reached (677.09 ± 102.34)pg/mL ,significantly higher than those whose NIHSS score≤ 6 points ,and the difference was statistically significant(P<0.05).Conclusion The increased level of plasma NT-proBNP is significant in judging the prog-nosis of patients with cerebral hemorrhage and can be used as the index for diagnosis and treatment of cerebral hemorrhage.