急性脑梗死患者血浆B型脑钠肽前体的表达与预后的相关性分析

摘要

目的：观察血浆 B 型脑钠肽前体的表达与急性脑梗死患者临床病理特征的关系及对预后的影响。方法选择我院收治的急性脑梗死患者65例，同期选择我院健康体检者50例为对照组；检测2组血浆 B 型脑钠肽前体（NT-proBNP）水平；采用美国国立卫生研究院卒中量表（NIHSS）评价患者的神经功能缺损程度，格拉斯哥昏迷评分（GCS）评价患者的昏迷程度；测定患者的脑梗死面积和血压情况；对所有患者行3个月随访，分析血浆 NT-proBNP 水平与急性脑梗死临床病理特征的关系。结果急性脑梗死患者血浆 NT-proBNP 水平明显高于对照组（P＜0.01）；急性脑梗死患者血浆 NT-proBNP 水平与NIHSS 评分、GCS 评分、脑梗死面积和高血压显著相关（P＜0.01），而与年龄、性别无明显相关（P ＞0.05）；急性脑梗死患者随访3个月，死亡16例，存活49例；死亡组患者入院时血浆 NT-proBNP 水平明显高于存活组，差异均有统计学意义（P ＜0.01）。结论血浆 NT-proBNP 水平可能是评估急性脑梗死患者病情变化和预后的重要指标之一。%Objective To discuss the expression of plasma B-type pro-brain natriuretic peptide and its relation to clinico-pathologic characteristic of patients with acute cerebral infarction and its effect on prognosis. Methods Sixty-five cases of a-cute cerebral infarction patients were selected in the neurology department of our hospital. During the same period ,50 cases of routine physical examinees in our hospital were chosen. Plasma B-type pro-brain natriuretic peptide(NT-proBNP) in 2 groups was detected. The National Institutes of Health Stroke Scale (NIHSS) was used to evaluate neurological deficits . The severity of coma was evaluated by Glasgow Coma Scale (GCS). The area of cerebral infarction and the blood pressure were measured. Three months clinical follow up were performed in all patients. The relationship between plasma NT-proBNP and clinicopatho-logic characteristic of acute cerebral infarction was analyzed. Results Plasma NT-proBNP in acute cerebral infarction patients was obviously higher than that of healthy control group(P< 0.01). Plasma NT-proBNP in acute cerebral infarction patients was obviously related to scores of NIHSS ,GCS ,the area of cerebral infarction and hypertension(P< 0.01) ,and was not signifi-cantly associated with age and sex (P > 0.05). Acute cerebral infarction patients were followed up for 3 months and among them ,16 patients died and 49 survived. Plasma NT-proBNP in death group on admission was obviously higher than that of the survival group(P< 0.01). Conclusion Plasma NT-proBNP may be one of the important indexes to evaluate the condition and prognosis of acute cerebral infarction patients .