脑梗死患者血清超敏C反应蛋白D-二聚体含量及颈动脉粥样硬化斑块的测定及分析

摘要

Objective To explore the changes and significances of levels of blood hs‐CRP ,D‐Dimer and carotid atheroscle‐rotic plaque in patients with acute cerebral infarction caused by internal carotid artery .Methods The levels of serum hs‐CRP and D‐Dimer in 85 patients who suffered from acute cerebral infarction for the first time were measured and were compared with that in normal controls .Carotid color ultrasonography was used to detect the carotid plaque .The relationships between the lev‐els of hs‐CRP ,D‐Dimer and carotid atherosclerotic plaque and NIHSS were analyzed .Results The blood levels of hs‐CRP ,D‐Di‐mer and the positive incidence of unstable plaque in patients with acute cerebral infarction were higher than that in the control group (all P< 0 .05);and patients with moderate‐heavy severity showed significantly higher levels and incidence than those with mild severity (all P<0 .05) .The levels of hs‐CRP and D‐Dimer in patients with unstable plaque were higher than that in patients without unstable plaque (P<0 .05) .The levels of both hs‐CRP and D‐Dimer were positively correlated with the NIH‐SS scores (r=0 .57 and 0 .38 ,respectively ,all P<0 .05) .Conclusion In order to predict and estimate the severity of acute cere‐bral infarction ,it is very valuable to observe the changes of levels of blood hs‐CRP ,D‐Dimer and the positive incidence of unsta‐ble plaque which are significantly increased in patients with acute cerebral infarction .%目的：探讨颈内动脉系统急性脑梗死患者血清超敏C反应蛋白（hs-CRP）、D-二聚体（D-Dimer）含量及颈动脉粥样硬化斑块的变化及意义。方法测定85例首次颈内动脉系统急性脑梗死患者血清hs-CRP和血浆D-Dimer含量，并与正常对照组进行比较；颈动脉彩超测定颈动脉粥样硬化斑块情况。分析血清hs-CRP、血浆D-Dimer含量、颈动脉粥样硬化斑块情况与神经功能缺损程度评分的关系。结果脑梗死组血清hs-CRP和血浆D-Dimer含量、不稳定斑块率明显高于正常对照组（均 P＜0.05），脑梗死中重度组明显高于轻度组（均 P＜0.05），伴不稳定斑块患者血清hs-CRP和血浆D-Dimer含量明显高于不伴不稳定斑块患者（P＜0.05）。脑梗死组hs-CRP和D-Dimer含量与NIHSS评分呈正相关（r＝0.57和0.38，均P＜0.05）。结论急性脑梗死患者血清hs-CRP及D-Dimer含量及不稳定斑块率明显增高，观察其情况对于预测脑梗死的发生和病情轻重具有重要意义。