血浆Aβ40、Aβ42早期诊断广泛性脑萎缩并认知功能障碍的价值

摘要

Objective To evaluate the predictive value of plasma Aβ40 and Aβ42 in early diagnosis of generalized brain atrophy complicated with cognitive dysfunction.Methods A total of 150 elderly patients with moderate and severe brain atrophy were examined by physical examination,magnetic resonance imaging,sex,age,blood pressure,triglyceride,cholesterol,low density lipoprotein,albumin and other general conditions.Subjects were divided into three groups according to the degree of cognitive function,normal group,mild cognitive impairment (MCI) group,dementia group.The levels of plasma Aβ40 and Aβ42 were measured by double antibody sandwich enzyme-linked immunosorbent assay.Results Aβ40,Aβ42 levels were significantly decreased in the MCI group;Aβ40,Aβ42 levels were positively correlated with MMSE score;Aβ40 was positively correlated with Aβ42.Conclusion Plasma Aβ40 and Aβ42 levels can be used as early biomarkers for the diagnosis of cognitive dysfunction in brain atrophy.%目的 探讨血浆Aβ40、Aβ42对广泛性脑萎缩并发认知功能障碍早期诊断的预测价值.方法 对150例中、重度广泛性脑萎缩的老年人进行健康体检、磁共振成像扫描,记录性别、年龄、血压、甘油三酯、胆固醇、低密度脂蛋白、白蛋白等一般情况.按认知功能程度不同分为3组,正常组、轻度认知功能障碍(MCI)组、痴呆组.应用双抗体夹心酶联免疫吸附法测定血浆Aβ40、Aβ42含量.结果 Aβ40、Aβ42水平在MCI组即已出现明显下降;Aβ4、Aβ42水平均与MMSE评分值呈正相关;Aβ40与Aβ42呈正相关.结论 血浆Aβ40、Aβ42水平可以作为脑萎缩老年人早期诊断认知功能损害的生物学标记物.