磁共振波谱分析在小儿外伤性脑梗死中的应用研究

摘要

Objective To investigate the 1H magnetic resonance spectroscopy feature of the brain metabolite in children with traumatic cerebral infarction .Methods The deta ,1H-MRS features of brain lesions and the contralateralnormal region in 30 children with traumatic cerebral infarction were viewed by using 3.0 MRI .The concentrations of metabolites including the ratios of N-acetyl aspartate to areatine (NAA/Cr) and choline-containing compounds to Cr(Cho/Cr) in the brain lesions and normal regions were statistically analyzed .Results MRI results indicated the single and multiple lesions in the brain ,which were involved in the basal ganglia and lateral ventricle .The 1H-MRS features within the lesions were all abnormal .Compared with the contralateral normal region ,NAA/Crand Cho/Cr ratio of brain lesion were decreased ,and NAA/Cr ratio of brain lesion was gradually decreasing from superacute stage ,acute stage ,subacute stage to chronic stage .Conclusion 1H-MRS examination is of great im-portance in early diagnosis and prognosis of traumatic cerebral infarction in children .%目的 通过氢质子波谱分析技术(1 H-MRS)探讨外伤性脑梗死患儿的脑部代谢产物的变化特征及其临床意义.方法 对30例外伤性脑梗死患儿进行回顾性分析,行头颅3.0TMRI扫描,以病变部位及对侧正常部位为感兴趣区(ROI)行1H-MRS检查.分别测定病灶区及对照区的NAA/Cr、Cho/Cr,并进行统计学分析.结果 MRI显示病灶为单发和多发并存,均累及基底节及侧脑室旁,1H-MRS均有异常.与对照区比较,病灶区NAA/Cr、Cho/Cr均降低.且超急性期、急性期、亚急性期及慢性期的NAA/Cr呈进行性下降.结论 1H-MRS检查对外伤性脑梗死患儿的早期诊断及预后评估有重要价值.