疏血通注射液治疗非ST段抬高型心肌梗死患者血栓调节蛋白、11-脱氢血栓烷素B2的变化及相关研究

摘要

Objective To investigate the states of injury of vascular endothelium and platelet activation in NSTEMI patients,and measure the levels of thrombomodulin,which is a marker of injury of vascular endothelium,and urinary 11-dehydrothromboxane B2 in patients,which is a molecular marker of activated platelet.And to investigate the relationship between the two markers.Methods The subjects included 80 patients with non-ST-segment elevation myocardial.The patients were divided into two groups,including the treatment group and control group.There were 40 cases in each group,in treatment group added shuxuetong injection in therapeusis.All patients were measured the thrombomodulin and the urinary levels of TXB2 after treatment with medicine.Resuits The levels of TM and TXB2 was significantly decreased compared with the normal control(P＜0.05).Conclusion The injury of vascular endothelium and the activated platelet are under the control group highly.It is effective added shuxuetong injection in therapeusis in non-ST-segment elevation myocardial infarction patients.It can reduce incidence of the disease and have a good prognosis.%目的 观察非ST段抬高型心肌梗死(NSTEMI)患者血管内皮细胞损伤及血小板活化状态的情况,测定反映内皮细胞损伤情况的血栓收缩蛋白(TM)的量及反映血小板活化状态尿11-脱氢血栓烷素B2的量,并观察两者之间的关系.方法 80例非ST段抬高型心肌梗死患者被分为两组,实验组和对照组各40例.其中实验组在治疗上加用疏血通注射液,所有的患者在应用药物治疗前后测定血栓收缩蛋白和尿11-脱氢血栓烷素B2含量.结果 实验组与正常对照组比较,血栓收缩蛋白和11-脱氢血栓烷素B2浓度降低,两组差异有统计学意义(P＜0.05).结论 实验组患者体内内皮细胞损伤情况和血小板活化程度都明显低于对照纽,对非ST段抬高型心肌梗死患者治疗上加用疏血通注射液是有效的,能减少病人发病率,对病人预后有利.