住院2型糖尿病患者血糖水平和血脂水平相关性研究

摘要

Objective To investigate the correlation of glucose level with blood lipid level in patients with type 2 diabetes.Methods The level of GLU,TG,TC,HDL-C and LDL-C,Apo A1,ApoB and Apo(a) of 344 inpatients with type 2 diabetes (T2DM group) and 80 healthy person (contuol group)were measured,then the results were compared and analyzed.Results The level of TG,TC,LDL-C,ApoB,Apo(a) of T2DM group was significantly higher than than those of control group,and level of HDL-C,ApoA was significantly lower than that of control group,the difference was significant (P ＜ 0.05).With glucose level increasing,the level of TG,TC,LDL-C,ApoB and Apo(a) increased accordingly,the level of HDL-C and ApoA1 decrease accordingly,and level of TG,TC,LDL-C,ApoB and Apo (a) had positive correlation with glucose level,correlation coefficients r were 0.148,0.180,0.141,0.218,0.250(P ＜0.01).Conclusions Each index level of blood lipid of inpatients with type 2 diabetes has significant difference with normal control group and has certain correlation with glucose level,this is maybe the reason that lead to cardiovascular complications of patients with type 2 diabetes.%目的 探讨住院2型糖尿病患者血糖水平与血脂水平之间的关系.方法 测定344例住院2型糖尿病患者(T2DM组)和80例健康体检者(对照组)空腹血糖(GLU)水平和三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白(a)[Apo(a)]水平,并对结果进行比较分析.结果 T2DM组TG、TC、LDL-C、ApoB、Apo(a)水平明显高于对照组,HDL-C、ApoA1水平明显低于对照组,差异有统计学意义(P＜0.05)；随着血糖升高,TG、TC、LDL-C、ApoB、Apo(a)水平相应的升高,HDL-C、ApoA1水平相应下降,其中TG、TC、LDL-C、ApoB、Apo(a)水平与血糖水平呈正相关,相关系数r分别为0.148、0.180、0.141、0.218、0.250(P＜0.01).结论 2型糖尿病患者血脂各项指标水平与正常对照组比较差异有统计学意义(P＜0.05),并与血糖水平具有一定相关性,可能是导致2型糖尿病患者心血管并发症的原因.